Wnt signalling in pituitary development and tumorigenesis

T. J.G. Chambers; A. Giles; G. Brabant; J. R.E. Davis

doi:10.1530/ERC-13-0005

Wnt signalling in pituitary development and tumorigenesis

T. J.G. Chambers, A. Giles, G. Brabant, J. R.E. Davis^*

^*Corresponding author for this work

Clinic of Internal Medicine I

University of Manchester

19 Citations (Scopus)

Abstract

Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas.

Original language	English
Journal	Endocrine-Related Cancer
Volume	20
Issue number	3
ISSN	1351-0088
DOIs	https://doi.org/10.1530/ERC-13-0005
Publication status	Published - 01.06.2013

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abstract = "Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas.",

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AB - Wnt signalling is activated in both pituitary organogenesis and its mature function. Wnt ligands and Wnt signalling pathways are critical for the regulation of the formation of the pituitary. In the mature pituitary, Wnt signalling pathways control cell activity and may stimulate cell proliferation in both physiological and pathological processes. This review compares Wnt signalling pathways active in the developing and mature pituitary and explores how this gives us further insight into the development of pituitary adenomas.

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Wnt signalling in pituitary development and tumorigenesis

Abstract

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