Wirksamkeit und Sicherheit von Fumarsäureestern bei Patienten mit Psoriasis und therapiepflichtigen Begleiterkrankungen - Eine retrospektive Datenerhebung (FACTS)

Translated title of the contribution: Efficacy and safety of fumaric acid esters in patients with psoriasis on medication for comorbid conditions - A retrospective evaluation (FACTS)

Diamant Thaçi*, Peter Weisenseel, Sandra Philipp, Thomas Rosenbach, Sebastian Rotterdam, Matthias Augustin, Marcus Neureither, Kristian Reich

*Corresponding author for this work
15 Citations (Scopus)

Abstract

Background Safety and efficacy of fumaric acid esters (FAE) in patients with psoriasis requiring treated comorbidit condition were investigated. Patients and Methods Data collected from 7 dermatology centers were used for a retrospective analysis of patients treated continuously with FAE for at least 6 weeks who required at least one medication for a comorbid condition. The records were analyzed at baseline and after 1, 3, 6, 12 and 24 months of therapy. Safety parameters were monitored and the severity of skin symptoms was assessed by 'Physician's Global Assessment' (PGA). Results A total of 69 patients with moderate to severe psoriasis and a mean duration of 27.4 months of continuous treatment were included in the study. In less than 5% were interactions between FAE and co-medications observed. Changes of hepatic, renal or hematological laboratory parameters were usually insignificant and required a modification of FAE treatment in less than 12% of the cases. The percentage of patients documented as markedly improved or clear was 61% after 6 months, 77% after 12 months, and 75% after 24 months of therapy. Conclusions In patients with moderate to severe psoriasis on co-medications, FAE were effective and safe without any noteworthy drug interactions.

Translated title of the contributionEfficacy and safety of fumaric acid esters in patients with psoriasis on medication for comorbid conditions - A retrospective evaluation (FACTS)
Original languageGerman
JournalJDDG - Journal of the German Society of Dermatology
Volume11
Issue number5
Pages (from-to)429-435
Number of pages7
ISSN1610-0379
DOIs
Publication statusPublished - 05.2013

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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