White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues

Khadijeh Abbasi; Reza Zarezadeh; Amir Valizadeh; Amir Mehdizadeh; Hamed Hamishehkar; Mohammad Nouri; Masoud Darabi

doi:10.1016/j.bcp.2023.116012

White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues

Khadijeh Abbasi, Reza Zarezadeh, Amir Valizadeh, Amir Mehdizadeh, Hamed Hamishehkar, Mohammad Nouri^*, Masoud Darabi

^*Corresponding author for this work

10 Citations (Scopus)

Abstract

This study highlights the therapeutic potential of activating brown adipose tissue (BAT) for managing polycystic ovary syndrome (PCOS), a prevalent endocrine disorder associated with metabolic and reproductive abnormalities. BAT plays a crucial role in regulating energy expenditure and systemic insulin sensitivity, making it an attractive target for the treatment of obesity and metabolic diseases. Recent research suggests that impaired BAT function and mass may contribute to the link between metabolic disturbances and reproductive issues in PCOS. Additionally, abnormal white adipose tissue (WAT) can exacerbate these conditions by releasing adipokines and nonesterified fatty acids. In this review, we explored the impact of WAT changes on BAT function in PCOS and discussed the potential of BAT activation as a therapeutic strategy to improve PCOS symptoms. We propose that BAT activation holds promise for managing PCOS; however, further research is needed to confirm its efficacy and to develop clinically feasible methods for BAT activation.

Original language	English
Article number	116012
Journal	Biochemical Pharmacology
Volume	220
Pages (from-to)	116012
ISSN	0006-2952
DOIs	https://doi.org/10.1016/j.bcp.2023.116012
Publication status	Published - 02.2024

Funding

This work received support from a grant provided by the Drug Applied Research Center, Tabriz University of Medical Sciences, Number: 68884. The first author acknowledges that this review is part of her PhD dissertation conducted at Tabriz University of Medical Sciences under the supervision of the last author.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)
Centers: University Cancer Center Schleswig-Holstein (UCCSH)
Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

2.22-14 Hematology, Oncology
2.22-21 Gynaecology and Obstetrics
2.22-17 Endocrinology, Diabetology, Metabolism

Access to Document

10.1016/j.bcp.2023.116012

Cite this

@article{1be46be8fa394b2c82fa510b225cbed1,

title = "White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues",

abstract = "This study highlights the therapeutic potential of activating brown adipose tissue (BAT) for managing polycystic ovary syndrome (PCOS), a prevalent endocrine disorder associated with metabolic and reproductive abnormalities. BAT plays a crucial role in regulating energy expenditure and systemic insulin sensitivity, making it an attractive target for the treatment of obesity and metabolic diseases. Recent research suggests that impaired BAT function and mass may contribute to the link between metabolic disturbances and reproductive issues in PCOS. Additionally, abnormal white adipose tissue (WAT) can exacerbate these conditions by releasing adipokines and nonesterified fatty acids. In this review, we explored the impact of WAT changes on BAT function in PCOS and discussed the potential of BAT activation as a therapeutic strategy to improve PCOS symptoms. We propose that BAT activation holds promise for managing PCOS; however, further research is needed to confirm its efficacy and to develop clinically feasible methods for BAT activation.",

author = "Khadijeh Abbasi and Reza Zarezadeh and Amir Valizadeh and Amir Mehdizadeh and Hamed Hamishehkar and Mohammad Nouri and Masoud Darabi",

year = "2024",

month = feb,

doi = "10.1016/j.bcp.2023.116012",

language = "English",

volume = "220",

pages = "116012",

journal = "Biochemical Pharmacology",

issn = "0006-2952",

publisher = "Elsevier Inc.",

}

TY - JOUR

T1 - White-brown adipose tissue interplay in polycystic ovary syndrome

T2 - Therapeutic avenues

AU - Abbasi, Khadijeh

AU - Zarezadeh, Reza

AU - Valizadeh, Amir

AU - Mehdizadeh, Amir

AU - Hamishehkar, Hamed

AU - Nouri, Mohammad

AU - Darabi, Masoud

PY - 2024/2

Y1 - 2024/2

N2 - This study highlights the therapeutic potential of activating brown adipose tissue (BAT) for managing polycystic ovary syndrome (PCOS), a prevalent endocrine disorder associated with metabolic and reproductive abnormalities. BAT plays a crucial role in regulating energy expenditure and systemic insulin sensitivity, making it an attractive target for the treatment of obesity and metabolic diseases. Recent research suggests that impaired BAT function and mass may contribute to the link between metabolic disturbances and reproductive issues in PCOS. Additionally, abnormal white adipose tissue (WAT) can exacerbate these conditions by releasing adipokines and nonesterified fatty acids. In this review, we explored the impact of WAT changes on BAT function in PCOS and discussed the potential of BAT activation as a therapeutic strategy to improve PCOS symptoms. We propose that BAT activation holds promise for managing PCOS; however, further research is needed to confirm its efficacy and to develop clinically feasible methods for BAT activation.

AB - This study highlights the therapeutic potential of activating brown adipose tissue (BAT) for managing polycystic ovary syndrome (PCOS), a prevalent endocrine disorder associated with metabolic and reproductive abnormalities. BAT plays a crucial role in regulating energy expenditure and systemic insulin sensitivity, making it an attractive target for the treatment of obesity and metabolic diseases. Recent research suggests that impaired BAT function and mass may contribute to the link between metabolic disturbances and reproductive issues in PCOS. Additionally, abnormal white adipose tissue (WAT) can exacerbate these conditions by releasing adipokines and nonesterified fatty acids. In this review, we explored the impact of WAT changes on BAT function in PCOS and discussed the potential of BAT activation as a therapeutic strategy to improve PCOS symptoms. We propose that BAT activation holds promise for managing PCOS; however, further research is needed to confirm its efficacy and to develop clinically feasible methods for BAT activation.

UR - https://www.scopus.com/pages/publications/85181575097

UR - https://www.mendeley.com/catalogue/4ad94775-a2cf-349a-950e-5f366297488f/

U2 - 10.1016/j.bcp.2023.116012

DO - 10.1016/j.bcp.2023.116012

M3 - Scientific review articles

C2 - 38159686

AN - SCOPUS:85181575097

SN - 0006-2952

VL - 220

SP - 116012

JO - Biochemical Pharmacology

JF - Biochemical Pharmacology

M1 - 116012

ER -

White-brown adipose tissue interplay in polycystic ovary syndrome: Therapeutic avenues

Abstract

Funding

UN SDGs

Research Areas and Centers

DFG Research Classification Scheme

Access to Document

Other files and links

Fingerprint

Cite this