When oxygen runs short: The microenvironment drives host-pathogen interactions

Inga Dietz; Stefan Jerchel; Márta Szaszák; Kensuke Shima; Jan Rupp

doi:10.1016/j.micinf.2011.11.003

When oxygen runs short: The microenvironment drives host-pathogen interactions

Inga Dietz, Stefan Jerchel, Márta Szaszák, Kensuke Shima, Jan Rupp^*

^*Corresponding author for this work

14 Citations (Scopus)

Abstract

Pathogens that colonize or infect the human body have to face varying oxygen concentrations within different organs. Inflammation itself promotes oxygen consumption within affected tissues and creates a low oxygen environment. As a consequence, pathogens and the host immune system have to adapt to rapid changes in oxygen availability. Here we summarize recent findings on the adaptation of pathogens, host defense mechanisms and treatment strategies against intracellular pathogens in a low oxygen environment.

Original language	English
Journal	Microbes and Infection
Volume	14
Issue number	4
Pages (from-to)	311-316
Number of pages	6
ISSN	1286-4579
DOIs	https://doi.org/10.1016/j.micinf.2011.11.003
Publication status	Published - 01.04.2012

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.micinf.2011.11.003

Cite this

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abstract = "Pathogens that colonize or infect the human body have to face varying oxygen concentrations within different organs. Inflammation itself promotes oxygen consumption within affected tissues and creates a low oxygen environment. As a consequence, pathogens and the host immune system have to adapt to rapid changes in oxygen availability. Here we summarize recent findings on the adaptation of pathogens, host defense mechanisms and treatment strategies against intracellular pathogens in a low oxygen environment.",

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AU - Szaszák, Márta

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AU - Rupp, Jan

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AB - Pathogens that colonize or infect the human body have to face varying oxygen concentrations within different organs. Inflammation itself promotes oxygen consumption within affected tissues and creates a low oxygen environment. As a consequence, pathogens and the host immune system have to adapt to rapid changes in oxygen availability. Here we summarize recent findings on the adaptation of pathogens, host defense mechanisms and treatment strategies against intracellular pathogens in a low oxygen environment.

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When oxygen runs short: The microenvironment drives host-pathogen interactions

Abstract

Research Areas and Centers

UN SDGs

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