When oxygen runs short: The microenvironment drives host-pathogen interactions

Inga Dietz, Stefan Jerchel, Márta Szaszák, Kensuke Shima, Jan Rupp*

*Corresponding author for this work
    14 Citations (Scopus)


    Pathogens that colonize or infect the human body have to face varying oxygen concentrations within different organs. Inflammation itself promotes oxygen consumption within affected tissues and creates a low oxygen environment. As a consequence, pathogens and the host immune system have to adapt to rapid changes in oxygen availability. Here we summarize recent findings on the adaptation of pathogens, host defense mechanisms and treatment strategies against intracellular pathogens in a low oxygen environment.

    Original languageEnglish
    JournalMicrobes and Infection
    Issue number4
    Pages (from-to)311-316
    Number of pages6
    Publication statusPublished - 01.04.2012

    Research Areas and Centers

    • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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