Wegenersche Granulomatose und ANCA-assoziierte Vaskulitiden: pathogenetische Konzepte zur Rolle von Autoantigenen, Autoantikörpern und Zytokinen.

Translated title of the contribution: Wegener's granulomatosis and ANCA-associated vasculitis: pathogenic role of autoantigens, autoantibodies, and cytokines

J. Kekow*, E. Csernok, C. H. Szymkowiak, W. L. Gross

*Corresponding author for this work

Abstract

A real explosion of data is seen concerning the detection of autoantibodies collectively known as antineutrophil cytoplasmic antibodies (ANCA) recognizing granule proteins of granulocytes and monocytes. Distinct fluorescence staining patterns result from their diverse substrate specificities, and can even identify several disease entities mainly in the etiopathogenetically unclear group of primary systemic vasculitides (PSV). The well-documented disease specificity of ANCA recognizing proteinase 3 (PR3), and recent in vitro findings concerning the effect of cytokines on immunocompetent cells including the endothelium are the rationale for the presentation of a new model explaining the development of systemic vasculitis.

Translated title of the contributionWegener's granulomatosis and ANCA-associated vasculitis: pathogenic role of autoantigens, autoantibodies, and cytokines
Original languageGerman
JournalImmunität und Infektion
Volume21 Suppl 1
Pages (from-to)44-48
Number of pages5
ISSN0340-1162
Publication statusPublished - 04.1993

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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