Weekly nab-paclitaxel in metastatic breast cancer - Summary and results of an expert panel discussion

Christian Jackisch*, Hans Joachim Lück, Michael Untch, Joachim Bischoff, Volkmar Müller, Marcus Schmidt, Marc Thill, Marion Kiechle

*Corresponding author for this work
5 Citations (Scopus)


Taxanes are regarded as the most effective single agents in the treatment of metastatic breast cancer (MBC). For conventional taxanes, crucial toxicities and impairments in clinical efficacy are related to solvents necessary because of the agents hydrophobicity. The mandatory premedication with corticosteroids causes additional side effects. Nab-paclitaxel is a solvent-free colloidal suspension of paclitaxel and human serum albumin that exploits the physiological transport properties of albumin. It is registered as monotherapy with a recommended dose of 260 mg/m2 every 3 weeks for the treatment of patients with MBC, who have failed a first-line treatment of metastatic disease and for whom a standard anthracycline treatment is not indicated. Clinical evidence is available for the registered 3-weekly administration and for alternative weekly schedules in first and further lines of therapy of patients with MBC. During an advisory board meeting, a group of 8 German breast cancer experts reviewed the clinical data of nab-paclitaxel in MBC and discussed how nab-paclitaxel could be used in clinical practice on the basis of the current data.

Original languageEnglish
JournalBreast Care
Issue number2
Pages (from-to)137-143
Number of pages7
Publication statusPublished - 01.01.2012


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