Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles

Vasyl Kilin; Gabriel Campargue; Ina Fureraj; Sim Sakong; Tarek Sabri; Florian Riporto; Alice Vieren; Yannick Mugnier; Christophe Mas; Davide Staedler; John Michael Collins; Luigi Bonacina; Alfred Vogel; John A. Capobianco; Jean Pierre Wolf

doi:10.1021/acsnano.9b08813

Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles

Vasyl Kilin, Gabriel Campargue, Ina Fureraj, Sim Sakong, Tarek Sabri, Florian Riporto, Alice Vieren, Yannick Mugnier, Christophe Mas, Davide Staedler, John Michael Collins, Luigi Bonacina, Alfred Vogel, John A. Capobianco, Jean Pierre Wolf

Institute of Biomedical Optics

4 Citations (Scopus)

Abstract

We introduce a nonlinear all-optical theranostics protocol based on the excitation wavelength decoupling between imaging and photoinduced damage of human cancer cells labeled by bismuth ferrite (BFO) harmonic nanoparticles (HNPs). To characterize the damage process, we rely on a scheme for in situ temperature monitoring based on upconversion nanoparticles: by spectrally resolving the emission of silica coated NaGdF4:Yb3+/Er3+ nanoparticles in close vicinity of a BFO HNP, we show that the photointeraction upon NIR-I excitation at high irradiance is associated with a temperature increase >100 °C. The observed laser-cell interaction implies a permanent change of the BFO nonlinear optical properties, which can be used as a proxy to read out the outcome of a theranostics procedure combining imaging at 980 nm and selective cell damage at 830 nm. The approach has potential applications to monitor and treat lesions within NIR light penetration depth in tissues.

Original language	English
Journal	ACS Nano
Volume	14
Issue number	4
Pages (from-to)	4087-4095
Number of pages	9
ISSN	1936-0851
DOIs	https://doi.org/10.1021/acsnano.9b08813
Publication status	Published - 28.04.2020

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Academic Focus: Biomedical Engineering

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10.1021/acsnano.9b08813

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Kilin, V., Campargue, G., Fureraj, I., Sakong, S., Sabri, T., Riporto, F., Vieren, A., Mugnier, Y., Mas, C., Staedler, D., Collins, J. M., Bonacina, L., Vogel, A., Capobianco, J. A., & Wolf, J. P. (2020). Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles. ACS Nano, 14(4), 4087-4095. https://doi.org/10.1021/acsnano.9b08813

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title = "Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles",

abstract = "We introduce a nonlinear all-optical theranostics protocol based on the excitation wavelength decoupling between imaging and photoinduced damage of human cancer cells labeled by bismuth ferrite (BFO) harmonic nanoparticles (HNPs). To characterize the damage process, we rely on a scheme for in situ temperature monitoring based on upconversion nanoparticles: by spectrally resolving the emission of silica coated NaGdF4:Yb3+/Er3+ nanoparticles in close vicinity of a BFO HNP, we show that the photointeraction upon NIR-I excitation at high irradiance is associated with a temperature increase >100 °C. The observed laser-cell interaction implies a permanent change of the BFO nonlinear optical properties, which can be used as a proxy to read out the outcome of a theranostics procedure combining imaging at 980 nm and selective cell damage at 830 nm. The approach has potential applications to monitor and treat lesions within NIR light penetration depth in tissues.",

author = "Vasyl Kilin and Gabriel Campargue and Ina Fureraj and Sim Sakong and Tarek Sabri and Florian Riporto and Alice Vieren and Yannick Mugnier and Christophe Mas and Davide Staedler and Collins, {John Michael} and Luigi Bonacina and Alfred Vogel and Capobianco, {John A.} and Wolf, {Jean Pierre}",

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Kilin, V, Campargue, G, Fureraj, I, Sakong, S, Sabri, T, Riporto, F, Vieren, A, Mugnier, Y, Mas, C, Staedler, D, Collins, JM, Bonacina, L, Vogel, A, Capobianco, JA & Wolf, JP 2020, 'Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles', ACS Nano, vol. 14, no. 4, pp. 4087-4095. https://doi.org/10.1021/acsnano.9b08813

TY - JOUR

T1 - Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles

AU - Kilin, Vasyl

AU - Campargue, Gabriel

AU - Fureraj, Ina

AU - Sakong, Sim

AU - Sabri, Tarek

AU - Riporto, Florian

AU - Vieren, Alice

AU - Mugnier, Yannick

AU - Mas, Christophe

AU - Staedler, Davide

AU - Collins, John Michael

AU - Bonacina, Luigi

AU - Vogel, Alfred

AU - Capobianco, John A.

AU - Wolf, Jean Pierre

N1 - Copyright: This record is sourced from MEDLINE/PubMed, a database of the U.S. National Library of Medicine

PY - 2020/4/28

Y1 - 2020/4/28

N2 - We introduce a nonlinear all-optical theranostics protocol based on the excitation wavelength decoupling between imaging and photoinduced damage of human cancer cells labeled by bismuth ferrite (BFO) harmonic nanoparticles (HNPs). To characterize the damage process, we rely on a scheme for in situ temperature monitoring based on upconversion nanoparticles: by spectrally resolving the emission of silica coated NaGdF4:Yb3+/Er3+ nanoparticles in close vicinity of a BFO HNP, we show that the photointeraction upon NIR-I excitation at high irradiance is associated with a temperature increase >100 °C. The observed laser-cell interaction implies a permanent change of the BFO nonlinear optical properties, which can be used as a proxy to read out the outcome of a theranostics procedure combining imaging at 980 nm and selective cell damage at 830 nm. The approach has potential applications to monitor and treat lesions within NIR light penetration depth in tissues.

AB - We introduce a nonlinear all-optical theranostics protocol based on the excitation wavelength decoupling between imaging and photoinduced damage of human cancer cells labeled by bismuth ferrite (BFO) harmonic nanoparticles (HNPs). To characterize the damage process, we rely on a scheme for in situ temperature monitoring based on upconversion nanoparticles: by spectrally resolving the emission of silica coated NaGdF4:Yb3+/Er3+ nanoparticles in close vicinity of a BFO HNP, we show that the photointeraction upon NIR-I excitation at high irradiance is associated with a temperature increase >100 °C. The observed laser-cell interaction implies a permanent change of the BFO nonlinear optical properties, which can be used as a proxy to read out the outcome of a theranostics procedure combining imaging at 980 nm and selective cell damage at 830 nm. The approach has potential applications to monitor and treat lesions within NIR light penetration depth in tissues.

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AN - SCOPUS:85084167159

SN - 1936-0851

VL - 14

SP - 4087

EP - 4095

JO - ACS Nano

JF - ACS Nano

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ER -

Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles

Abstract

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