Wavelength-Selective Nonlinear Imaging and Photo-Induced Cell Damage by Dielectric Harmonic Nanoparticles

Vasyl Kilin, Gabriel Campargue, Ina Fureraj, Sim Sakong, Tarek Sabri, Florian Riporto, Alice Vieren, Yannick Mugnier, Christophe Mas, Davide Staedler, John Michael Collins, Luigi Bonacina, Alfred Vogel, John A. Capobianco, Jean Pierre Wolf

4 Citations (Scopus)


We introduce a nonlinear all-optical theranostics protocol based on the excitation wavelength decoupling between imaging and photoinduced damage of human cancer cells labeled by bismuth ferrite (BFO) harmonic nanoparticles (HNPs). To characterize the damage process, we rely on a scheme for in situ temperature monitoring based on upconversion nanoparticles: by spectrally resolving the emission of silica coated NaGdF4:Yb3+/Er3+ nanoparticles in close vicinity of a BFO HNP, we show that the photointeraction upon NIR-I excitation at high irradiance is associated with a temperature increase >100 °C. The observed laser-cell interaction implies a permanent change of the BFO nonlinear optical properties, which can be used as a proxy to read out the outcome of a theranostics procedure combining imaging at 980 nm and selective cell damage at 830 nm. The approach has potential applications to monitor and treat lesions within NIR light penetration depth in tissues.

Original languageEnglish
JournalACS Nano
Issue number4
Pages (from-to)4087-4095
Number of pages9
Publication statusPublished - 28.04.2020

Research Areas and Centers

  • Academic Focus: Biomedical Engineering


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