Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman

Thomas Elter; Michal Sieniawski; Axel Gossmann; Claudia Wickenhauser; Ursula Schröder; Harald Seifert; Johannes Kuchta; Jürgen Burhenne; Klaus Dieter Riedel; Gerd Fätkenheuer; Oliver A. Cornely

doi:10.1016/j.ijantimicag.2006.04.006

Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman

Thomas Elter, Michal Sieniawski^*, Axel Gossmann, Claudia Wickenhauser, Ursula Schröder, Harald Seifert, Johannes Kuchta, Jürgen Burhenne, Klaus Dieter Riedel, Gerd Fätkenheuer, Oliver A. Cornely

^*Corresponding author for this work

Department of Otorhinolaryngology, Phoniatrics and Pediatric Audiology

49 Citations (Scopus)

Abstract

Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient responded successfully to salvage combination treatment with voriconazole and caspofungin. Furthermore, for the first time, voriconazole levels in an intracerebral abscess were measured in this patient undergoing voriconazole oral therapy.

Original language	English
Journal	International Journal of Antimicrobial Agents
Volume	28
Issue number	3
Pages (from-to)	262-265
Number of pages	4
ISSN	0924-8579
DOIs	https://doi.org/10.1016/j.ijantimicag.2006.04.006
Publication status	Published - 09.2006

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SDG 3 Good Health and Well-being

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10.1016/j.ijantimicag.2006.04.006

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Elter, T., Sieniawski, M., Gossmann, A., Wickenhauser, C., Schröder, U., Seifert, H., Kuchta, J., Burhenne, J., Riedel, K. D., Fätkenheuer, G., & Cornely, O. A. (2006). Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman. International Journal of Antimicrobial Agents, 28(3), 262-265. https://doi.org/10.1016/j.ijantimicag.2006.04.006

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abstract = "Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90\%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient responded successfully to salvage combination treatment with voriconazole and caspofungin. Furthermore, for the first time, voriconazole levels in an intracerebral abscess were measured in this patient undergoing voriconazole oral therapy.",

author = "Thomas Elter and Michal Sieniawski and Axel Gossmann and Claudia Wickenhauser and Ursula Schr{\"o}der and Harald Seifert and Johannes Kuchta and J{\"u}rgen Burhenne and Riedel, \{Klaus Dieter\} and Gerd F{\"a}tkenheuer and Cornely, \{Oliver A.\}",

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Elter, T, Sieniawski, M, Gossmann, A, Wickenhauser, C, Schröder, U, Seifert, H, Kuchta, J, Burhenne, J, Riedel, KD, Fätkenheuer, G & Cornely, OA 2006, 'Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman', International Journal of Antimicrobial Agents, vol. 28, no. 3, pp. 262-265. https://doi.org/10.1016/j.ijantimicag.2006.04.006

TY - JOUR

T1 - Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman

AU - Elter, Thomas

AU - Sieniawski, Michal

AU - Gossmann, Axel

AU - Wickenhauser, Claudia

AU - Schröder, Ursula

AU - Seifert, Harald

AU - Kuchta, Johannes

AU - Burhenne, Jürgen

AU - Riedel, Klaus Dieter

AU - Fätkenheuer, Gerd

AU - Cornely, Oliver A.

PY - 2006/9

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N2 - Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient responded successfully to salvage combination treatment with voriconazole and caspofungin. Furthermore, for the first time, voriconazole levels in an intracerebral abscess were measured in this patient undergoing voriconazole oral therapy.

AB - Invasive aspergillosis of the central nervous system has a mortality rate exceeding 90%. We describe a 29-year-old woman with a medical history of chronic polyarthritis who developed a proven rhinocerebral Aspergillus fumigatus infection refractory to first-line treatment with liposomal amphotericin B. The patient responded successfully to salvage combination treatment with voriconazole and caspofungin. Furthermore, for the first time, voriconazole levels in an intracerebral abscess were measured in this patient undergoing voriconazole oral therapy.

UR - https://www.scopus.com/pages/publications/33747133236

U2 - 10.1016/j.ijantimicag.2006.04.006

DO - 10.1016/j.ijantimicag.2006.04.006

M3 - Journal articles

C2 - 16908120

AN - SCOPUS:33747133236

SN - 0924-8579

VL - 28

SP - 262

EP - 265

JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 3

ER -

Voriconazole brain tissue levels in rhinocerebral aspergillosis in a successfully treated young woman

Abstract

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