Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy

M. J. Voogt; H. Trillaud; Y. S. Kim; W. P.Th M. Mali; J. Barkhausen; L. W. Bartels; R. Deckers; N. Frulio; H. Rhim; H. K. Lim; T. Eckey; H. J. Nieminen; C. Mougenot; B. Keserci; J. Soini; T. Vaara; M. O. Köhler; S. Sokka; Maurice A.A.J. Van Den Bosch

doi:10.1007/s00330-011-2262-8

Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy

M. J. Voogt, H. Trillaud, Y. S. Kim, W. P.Th M. Mali, J. Barkhausen, L. W. Bartels, R. Deckers, N. Frulio, H. Rhim, H. K. Lim, T. Eckey, H. J. Nieminen, C. Mougenot, B. Keserci, J. Soini, T. Vaara, M. O. Köhler, S. Sokka, Maurice A.A.J. Van Den Bosch^*

^*Corresponding author for this work

77 Citations (Scopus)

Abstract

Objective: The purpose of this prospective multicenter study was to assess the safety and technical feasibility of volumetric Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) ablation for treatment of patients with symptomatic uterine fibroids. Methods: Thirty-three patients with 36 fibroids were treated with volumetric MR-HIFU ablation. Treatment capability and technical feasibility were assessed by comparison of the Non-Perfused Volumes (NPVs) with MR thermal dose predicted treatment volumes. Safety was determined by evaluation of complications or adverse events and unintended lesions. Secondary endpoints were pain and discomfort scores, recovery time and length of hospital stay. Results: The mean NPV calculated as a percentage of the total fibroid volume was 21.7%. Correlation between the predicted treatment volumes and NPVs was found to be very strong, with a correlation coefficient r of 0.87. All patients tolerated the treatment well and were treated on an outpatient basis. No serious adverse events were reported and recovery time to normal activities was 2.3 ± 1.8 days. Conclusion: This prospective multicenter study proved that volumetric MR-HIFU is safe and technically feasible for the treatment of symptomatic uterine fibroids. Key Points: • Magnetic-resonance-guided high intensity focused ultrasound allows non-invasive treatment of uterine fibroids. • Volumetric feedback ablation is a novel technology that allows larger treatment volumes • MR-guided ultrasound ablation of uterine fibroids appears safe using volumetric feedback

Original language	English
Journal	European Radiology
Volume	22
Issue number	2
Pages (from-to)	411-417
Number of pages	7
ISSN	0938-7994
DOIs	https://doi.org/10.1007/s00330-011-2262-8
Publication status	Published - 01.02.2012

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Voogt, M. J., Trillaud, H., Kim, Y. S., Mali, W. P. T. M., Barkhausen, J., Bartels, L. W., Deckers, R., Frulio, N., Rhim, H., Lim, H. K., Eckey, T., Nieminen, H. J., Mougenot, C., Keserci, B., Soini, J., Vaara, T., Köhler, M. O., Sokka, S., & Van Den Bosch, M. A. A. J. (2012). Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy. European Radiology, 22(2), 411-417. https://doi.org/10.1007/s00330-011-2262-8

@article{996d791325d14fd88e317e88ac297158,

title = "Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy",

abstract = "Objective: The purpose of this prospective multicenter study was to assess the safety and technical feasibility of volumetric Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) ablation for treatment of patients with symptomatic uterine fibroids. Methods: Thirty-three patients with 36 fibroids were treated with volumetric MR-HIFU ablation. Treatment capability and technical feasibility were assessed by comparison of the Non-Perfused Volumes (NPVs) with MR thermal dose predicted treatment volumes. Safety was determined by evaluation of complications or adverse events and unintended lesions. Secondary endpoints were pain and discomfort scores, recovery time and length of hospital stay. Results: The mean NPV calculated as a percentage of the total fibroid volume was 21.7%. Correlation between the predicted treatment volumes and NPVs was found to be very strong, with a correlation coefficient r of 0.87. All patients tolerated the treatment well and were treated on an outpatient basis. No serious adverse events were reported and recovery time to normal activities was 2.3 ± 1.8 days. Conclusion: This prospective multicenter study proved that volumetric MR-HIFU is safe and technically feasible for the treatment of symptomatic uterine fibroids. Key Points: • Magnetic-resonance-guided high intensity focused ultrasound allows non-invasive treatment of uterine fibroids. • Volumetric feedback ablation is a novel technology that allows larger treatment volumes • MR-guided ultrasound ablation of uterine fibroids appears safe using volumetric feedback",

author = "Voogt, {M. J.} and H. Trillaud and Kim, {Y. S.} and Mali, {W. P.Th M.} and J. Barkhausen and Bartels, {L. W.} and R. Deckers and N. Frulio and H. Rhim and Lim, {H. K.} and T. Eckey and Nieminen, {H. J.} and C. Mougenot and B. Keserci and J. Soini and T. Vaara and K{\"o}hler, {M. O.} and S. Sokka and {Van Den Bosch}, {Maurice A.A.J.}",

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doi = "10.1007/s00330-011-2262-8",

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Voogt, MJ, Trillaud, H, Kim, YS, Mali, WPTM, Barkhausen, J, Bartels, LW, Deckers, R, Frulio, N, Rhim, H, Lim, HK, Eckey, T, Nieminen, HJ, Mougenot, C, Keserci, B, Soini, J, Vaara, T, Köhler, MO, Sokka, S & Van Den Bosch, MAAJ 2012, 'Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy', European Radiology, vol. 22, no. 2, pp. 411-417. https://doi.org/10.1007/s00330-011-2262-8

TY - JOUR

T1 - Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy

AU - Voogt, M. J.

AU - Trillaud, H.

AU - Kim, Y. S.

AU - Mali, W. P.Th M.

AU - Barkhausen, J.

AU - Bartels, L. W.

AU - Deckers, R.

AU - Frulio, N.

AU - Rhim, H.

AU - Lim, H. K.

AU - Eckey, T.

AU - Nieminen, H. J.

AU - Mougenot, C.

AU - Keserci, B.

AU - Soini, J.

AU - Vaara, T.

AU - Köhler, M. O.

AU - Sokka, S.

AU - Van Den Bosch, Maurice A.A.J.

PY - 2012/2/1

Y1 - 2012/2/1

N2 - Objective: The purpose of this prospective multicenter study was to assess the safety and technical feasibility of volumetric Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) ablation for treatment of patients with symptomatic uterine fibroids. Methods: Thirty-three patients with 36 fibroids were treated with volumetric MR-HIFU ablation. Treatment capability and technical feasibility were assessed by comparison of the Non-Perfused Volumes (NPVs) with MR thermal dose predicted treatment volumes. Safety was determined by evaluation of complications or adverse events and unintended lesions. Secondary endpoints were pain and discomfort scores, recovery time and length of hospital stay. Results: The mean NPV calculated as a percentage of the total fibroid volume was 21.7%. Correlation between the predicted treatment volumes and NPVs was found to be very strong, with a correlation coefficient r of 0.87. All patients tolerated the treatment well and were treated on an outpatient basis. No serious adverse events were reported and recovery time to normal activities was 2.3 ± 1.8 days. Conclusion: This prospective multicenter study proved that volumetric MR-HIFU is safe and technically feasible for the treatment of symptomatic uterine fibroids. Key Points: • Magnetic-resonance-guided high intensity focused ultrasound allows non-invasive treatment of uterine fibroids. • Volumetric feedback ablation is a novel technology that allows larger treatment volumes • MR-guided ultrasound ablation of uterine fibroids appears safe using volumetric feedback

AB - Objective: The purpose of this prospective multicenter study was to assess the safety and technical feasibility of volumetric Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) ablation for treatment of patients with symptomatic uterine fibroids. Methods: Thirty-three patients with 36 fibroids were treated with volumetric MR-HIFU ablation. Treatment capability and technical feasibility were assessed by comparison of the Non-Perfused Volumes (NPVs) with MR thermal dose predicted treatment volumes. Safety was determined by evaluation of complications or adverse events and unintended lesions. Secondary endpoints were pain and discomfort scores, recovery time and length of hospital stay. Results: The mean NPV calculated as a percentage of the total fibroid volume was 21.7%. Correlation between the predicted treatment volumes and NPVs was found to be very strong, with a correlation coefficient r of 0.87. All patients tolerated the treatment well and were treated on an outpatient basis. No serious adverse events were reported and recovery time to normal activities was 2.3 ± 1.8 days. Conclusion: This prospective multicenter study proved that volumetric MR-HIFU is safe and technically feasible for the treatment of symptomatic uterine fibroids. Key Points: • Magnetic-resonance-guided high intensity focused ultrasound allows non-invasive treatment of uterine fibroids. • Volumetric feedback ablation is a novel technology that allows larger treatment volumes • MR-guided ultrasound ablation of uterine fibroids appears safe using volumetric feedback

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C2 - 21901565

AN - SCOPUS:84856609858

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VL - 22

SP - 411

EP - 417

JO - European Radiology

JF - European Radiology

IS - 2

ER -

Volumetric feedback ablation of uterine fibroids using magnetic resonance-guided high intensity focused ultrasound therapy

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