Visualizing hormone actions in the brain

Georg Brabant; John Cain; Alan Jackson; Ilonka Kreitschmann-Andermahr

doi:10.1016/j.tem.2011.01.004

Visualizing hormone actions in the brain

Georg Brabant^*, John Cain, Alan Jackson, Ilonka Kreitschmann-Andermahr

^*Corresponding author for this work

Department of Internal Medicine I

11 Citations (Scopus)

Abstract

Profound and multifaceted effects of hormones on the development, maturation and function of the CNS are well documented. Recent developments in magnetic resonance imagining (MRI) and positron emission tomography (PET) permit detailed in vivo studies of cerebral structure and function in humans. Techniques to measure subtle differences in cerebral structure, regional brain activation, changes in blood flow and other physiological biomarkers allow us to translate experimental evidence of hormone effects obtained from animal models to humans. Here we review the imaging techniques available to support studies of hormone effects on the CNS, emphasizing the recent developments of MRI. In summarizing the major current studies we discuss the potential of these techniques for an emerging new field in endocrinology.

Original language	English
Journal	Trends in Endocrinology and Metabolism
Volume	22
Issue number	5
Pages (from-to)	153-163
Number of pages	11
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2011.01.004
Publication status	Published - 01.05.2011

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10.1016/j.tem.2011.01.004

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AU - Cain, John

AU - Jackson, Alan

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N2 - Profound and multifaceted effects of hormones on the development, maturation and function of the CNS are well documented. Recent developments in magnetic resonance imagining (MRI) and positron emission tomography (PET) permit detailed in vivo studies of cerebral structure and function in humans. Techniques to measure subtle differences in cerebral structure, regional brain activation, changes in blood flow and other physiological biomarkers allow us to translate experimental evidence of hormone effects obtained from animal models to humans. Here we review the imaging techniques available to support studies of hormone effects on the CNS, emphasizing the recent developments of MRI. In summarizing the major current studies we discuss the potential of these techniques for an emerging new field in endocrinology.

AB - Profound and multifaceted effects of hormones on the development, maturation and function of the CNS are well documented. Recent developments in magnetic resonance imagining (MRI) and positron emission tomography (PET) permit detailed in vivo studies of cerebral structure and function in humans. Techniques to measure subtle differences in cerebral structure, regional brain activation, changes in blood flow and other physiological biomarkers allow us to translate experimental evidence of hormone effects obtained from animal models to humans. Here we review the imaging techniques available to support studies of hormone effects on the CNS, emphasizing the recent developments of MRI. In summarizing the major current studies we discuss the potential of these techniques for an emerging new field in endocrinology.

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JO - Trends in Endocrinology and Metabolism

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Visualizing hormone actions in the brain

Abstract

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