Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging

Livia S. Eberlin, John V. Mulcahy, Alexander Tzabazis, Jialing Zhang, Huwei Liu, Matthew M. Logan, Heather J. Roberts, Gordon K. Lee, David C. Yeomans, Justin Du Bois*, Richard N. Zare

*Corresponding author for this work
18 Citations (Scopus)


Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass spectrometry imaging method for visualizing skin penetration of sodium channel modulators, including novel synthetic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin. Our simple and label-free approach enables successful mapping of the transverse and lateral diffusion of small molecules having different physicochemical properties without the need for extensive sample preparation.

Original languageEnglish
JournalJournal of the American Chemical Society
Issue number17
Pages (from-to)6401-6405
Number of pages5
Publication statusPublished - 30.04.2014


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