Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging

Livia S. Eberlin; John V. Mulcahy; Alexander Tzabazis; Jialing Zhang; Huwei Liu; Matthew M. Logan; Heather J. Roberts; Gordon K. Lee; David C. Yeomans; Justin Du Bois; Richard N. Zare

doi:10.1021/ja501635u

Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging

Livia S. Eberlin, John V. Mulcahy, Alexander Tzabazis, Jialing Zhang, Huwei Liu, Matthew M. Logan, Heather J. Roberts, Gordon K. Lee, David C. Yeomans, Justin Du Bois^*, Richard N. Zare

^*Corresponding author for this work

Clinic of Anesthesiology

18 Citations (Scopus)

Abstract

Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass spectrometry imaging method for visualizing skin penetration of sodium channel modulators, including novel synthetic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin. Our simple and label-free approach enables successful mapping of the transverse and lateral diffusion of small molecules having different physicochemical properties without the need for extensive sample preparation.

Original language	English
Journal	Journal of the American Chemical Society
Volume	136
Issue number	17
Pages (from-to)	6401-6405
Number of pages	5
ISSN	0002-7863
DOIs	https://doi.org/10.1021/ja501635u
Publication status	Published - 30.04.2014

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10.1021/ja501635u

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title = "Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging",

abstract = "Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass spectrometry imaging method for visualizing skin penetration of sodium channel modulators, including novel synthetic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin. Our simple and label-free approach enables successful mapping of the transverse and lateral diffusion of small molecules having different physicochemical properties without the need for extensive sample preparation.",

author = "Eberlin, {Livia S.} and Mulcahy, {John V.} and Alexander Tzabazis and Jialing Zhang and Huwei Liu and Logan, {Matthew M.} and Roberts, {Heather J.} and Lee, {Gordon K.} and Yeomans, {David C.} and {Du Bois}, Justin and Zare, {Richard N.}",

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T1 - Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging

AU - Eberlin, Livia S.

AU - Mulcahy, John V.

AU - Tzabazis, Alexander

AU - Zhang, Jialing

AU - Liu, Huwei

AU - Logan, Matthew M.

AU - Roberts, Heather J.

AU - Lee, Gordon K.

AU - Yeomans, David C.

AU - Du Bois, Justin

AU - Zare, Richard N.

PY - 2014/4/30

Y1 - 2014/4/30

N2 - Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass spectrometry imaging method for visualizing skin penetration of sodium channel modulators, including novel synthetic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin. Our simple and label-free approach enables successful mapping of the transverse and lateral diffusion of small molecules having different physicochemical properties without the need for extensive sample preparation.

AB - Determining permeability of a given compound through human skin is a principal challenge owing to the highly complex nature of dermal tissue. We describe the application of an ambient mass spectrometry imaging method for visualizing skin penetration of sodium channel modulators, including novel synthetic analogs of natural neurotoxic alkaloids, topically applied ex vivo to human skin. Our simple and label-free approach enables successful mapping of the transverse and lateral diffusion of small molecules having different physicochemical properties without the need for extensive sample preparation.

UR - http://www.scopus.com/inward/record.url?scp=84899747363&partnerID=8YFLogxK

U2 - 10.1021/ja501635u

DO - 10.1021/ja501635u

M3 - Journal articles

C2 - 24708172

AN - SCOPUS:84899747363

SN - 0002-7863

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SP - 6401

EP - 6405

JO - Journal of the American Chemical Society

JF - Journal of the American Chemical Society

IS - 17

ER -

Visualizing dermal permeation of sodium channel modulators by mass spectrometric imaging

Abstract

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