Abstract
One of the key questions in virology is how viruses, encoding relatively few genes, gain temporary or constant control over their hosts. To understand pathogenicity of a virus it is important to gain knowledge on the function of the individual viral proteins in the host cell, on their interactions with viral and cellular proteins and on the consequences of these interactions on cellular signaling pathways. A combination of transcriptomics, proteomics, high-throughput technologies and the bioinformatical analysis of the respective data help to elucidate specific cellular antiviral drug target candidates. In addition, viral and human interactome analyses indicate that different viruses target common, central human proteins for entering cellular signaling pathways and machineries which might constitute powerful broad-spectrum antiviral targets.
| Original language | English |
|---|---|
| Journal | Current Opinion in Virology |
| Volume | 2 |
| Issue number | 5 |
| Pages (from-to) | 614-621 |
| Number of pages | 8 |
| ISSN | 1879-6257 |
| DOIs | |
| Publication status | Published - 01.01.2012 |
Funding
This work was supported by a grant of the ‘Bundesministerium für Bildung und Forschung’ of the German Federal Government (Zoonosis Network, Consortium on ecology and pathogenesisis of SARS, project code 01KI1005A,F; http://www.gesundheitsforschung-bmbf.de/de/1721.php# SARS) to AvB. RH is supported by the DFG through its Cluster of Excellence ‘Inflammation at Interfaces’ (EXC 306), by the Fonds der Chemischen Industrie , by the Chinese Academy of Sciences through a Visiting Professorship for Senior International Scientists (grant no. 2010T1S6 ), and the Schleswig-Holstein Innovation Fund . He also thanks the European Commission for support through its SILVER project (contract no. HEALTH-F3-2010-260644).
