Abstract
Viral genomes show unequalled diversity, ranging from single-stranded DNA to double-stranded RNA. Moreover, viruses can quickly adapt to the host's immune response and drug treatment. Although they tend to make optimal use of the host cell's reservoir of proteins, viruses need to carry some enzymatic functions with them, as they may not be available or accessible in the infected cell. Recently, progress has been made in our structural understanding of viral enzymes involved in all stages of the viral life cycle, which includes entry, hijack, replication and exit stages.
| Original language | English |
|---|---|
| Journal | Current Opinion in Structural Biology |
| Volume | 16 |
| Issue number | 6 |
| Pages (from-to) | 776-786 |
| Number of pages | 11 |
| ISSN | 0959-440X |
| DOIs | |
| Publication status | Published - 01.12.2006 |
Funding
The authors acknowledge support by the European Commission through VIZIER (Comparative Structural Genomics of Viral Enzymes Involved in Replication; contract LSHG-CT-2004-511960) and SEPSDA (Sino-European Project on SARS Diagnostics and Antivirals; contract SP22-CT-2004-003831). RH thanks the Innovation Fund of the Government of Schleswig-Holstein and the Fonds der Chemischen Industrie for continuous support. Figures were prepared with the PyMol molecular graphics system (DeLano Scientific LLC, South San Francisco, CA, USA).
Research Areas and Centers
- Academic Focus: Center for Infection and Inflammation Research (ZIEL)
