Abstract
The Fc fragments of pathogenic IgG autoantibodies in patients with rheumatoid arthritis are low-galactosylated and low-sialylated. In contrast, high-galactosylated and high-sialylated antigen-specific IgG antibodies are sufficient to inhibit a pro-inflammatory immune response in an antigen-specific manner and might be a promising therapeutic tool to re-establish tolerance against defined self-antigens in autoimmune patients.
| Translated title of the contribution | Glycosylation-dependent effector function of IgG antibodies |
|---|---|
| Original language | German |
| Journal | Zeitschrift fur Rheumatologie |
| Volume | 71 |
| Issue number | 9 |
| Pages (from-to) | 798-800 |
| Number of pages | 3 |
| ISSN | 0340-1855 |
| DOIs | |
| Publication status | Published - 01.11.2012 |
