The Fc fragments of pathogenic IgG autoantibodies in patients with rheumatoid arthritis are low-galactosylated and low-sialylated. In contrast, high-galactosylated and high-sialylated antigen-specific IgG antibodies are sufficient to inhibit a pro-inflammatory immune response in an antigen-specific manner and might be a promising therapeutic tool to re-establish tolerance against defined self-antigens in autoimmune patients.
|Translated title of the contribution||Glycosylation-dependent effector function of IgG antibodies|
|Journal||Zeitschrift fur Rheumatologie|
|Number of pages||3|
|Publication status||Published - 01.11.2012|