Verzuckerungsabhängiger Wirkmechanismus von Antikörpern

Translated title of the contribution: Glycosylation-dependent effector function of IgG antibodies

M. Ehlers*

*Corresponding author for this work
1 Citation (Scopus)


The Fc fragments of pathogenic IgG autoantibodies in patients with rheumatoid arthritis are low-galactosylated and low-sialylated. In contrast, high-galactosylated and high-sialylated antigen-specific IgG antibodies are sufficient to inhibit a pro-inflammatory immune response in an antigen-specific manner and might be a promising therapeutic tool to re-establish tolerance against defined self-antigens in autoimmune patients.

Translated title of the contributionGlycosylation-dependent effector function of IgG antibodies
Original languageGerman
JournalZeitschrift fur Rheumatologie
Issue number9
Pages (from-to)798-800
Number of pages3
Publication statusPublished - 01.11.2012


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