Very low birth weight infants as a model to study genetic influences on neonatal weight gain

Juliane Spiegler; Evelyn Kattner; Matthias Vochem; Helmuth Küster; Jens Möller; Dirk Müller; Angela Kribs; Hugo Segerer; Christian Wieg; Werner Nikischin; Axel Von Der Wense; Corinna Gebauer; Egbert Herting; Wolfgang Göpel

doi:10.1097/01.mpg.0000304466.45541.f2

Very low birth weight infants as a model to study genetic influences on neonatal weight gain

Juliane Spiegler^*, Evelyn Kattner, Matthias Vochem, Helmuth Küster, Jens Möller, Dirk Müller, Angela Kribs, Hugo Segerer, Christian Wieg, Werner Nikischin, Axel Von Der Wense, Corinna Gebauer, Egbert Herting, Wolfgang Göpel

^*Corresponding author for this work

Clinic of Pediatric and Adolescent Medicine

6 Citations (Scopus)

Abstract

In a cohort of 829 preterm infants (birth weight below 1500 g) we identified 13 monozygotic, 10 same-sex dizygotic, and 12 same-sex matched singleton pairs. The difference in daily weight gain within pairs was significantly lower in monozygotic twins compared with dizygotic twins or matched singleton pairs. Our data support a strong genetic influence on postnatal growth in preterm infants. Therefore, weight gain of preterm infants may be an interesting model to study polymorphic variants of genes regulating neonatal resorption, metabolism, or energy expenditure, and their influence on weight gain in preterm infants.

Original language	English
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	46
Issue number	1
Pages (from-to)	113-116
Number of pages	4
ISSN	0277-2116
DOIs	https://doi.org/10.1097/01.mpg.0000304466.45541.f2
Publication status	Published - 01.2008

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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Spiegler, J., Kattner, E., Vochem, M., Küster, H., Möller, J., Müller, D., Kribs, A., Segerer, H., Wieg, C., Nikischin, W., Wense, A. V. D., Gebauer, C., Herting, E., & Göpel, W. (2008). Very low birth weight infants as a model to study genetic influences on neonatal weight gain. Journal of Pediatric Gastroenterology and Nutrition, 46(1), 113-116. https://doi.org/10.1097/01.mpg.0000304466.45541.f2

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Spiegler, J, Kattner, E, Vochem, M, Küster, H, Möller, J, Müller, D, Kribs, A, Segerer, H, Wieg, C, Nikischin, W, Wense, AVD, Gebauer, C, Herting, E & Göpel, W 2008, 'Very low birth weight infants as a model to study genetic influences on neonatal weight gain', Journal of Pediatric Gastroenterology and Nutrition, vol. 46, no. 1, pp. 113-116. https://doi.org/10.1097/01.mpg.0000304466.45541.f2

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AU - Spiegler, Juliane

AU - Kattner, Evelyn

AU - Vochem, Matthias

AU - Küster, Helmuth

AU - Möller, Jens

AU - Müller, Dirk

AU - Kribs, Angela

AU - Segerer, Hugo

AU - Wieg, Christian

AU - Nikischin, Werner

AU - Wense, Axel Von Der

AU - Gebauer, Corinna

AU - Herting, Egbert

AU - Göpel, Wolfgang

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AB - In a cohort of 829 preterm infants (birth weight below 1500 g) we identified 13 monozygotic, 10 same-sex dizygotic, and 12 same-sex matched singleton pairs. The difference in daily weight gain within pairs was significantly lower in monozygotic twins compared with dizygotic twins or matched singleton pairs. Our data support a strong genetic influence on postnatal growth in preterm infants. Therefore, weight gain of preterm infants may be an interesting model to study polymorphic variants of genes regulating neonatal resorption, metabolism, or energy expenditure, and their influence on weight gain in preterm infants.

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Very low birth weight infants as a model to study genetic influences on neonatal weight gain

Abstract

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UN SDGs

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