Vertical sleeve gastrectomy improves social behaviors in obese, male mice

Anne Marie Neumann; Cathleen Geißler; Randy Seeley; Henriette Kirchner; Henrik Oster

doi:10.1016/j.orcp.2025.02.003

Vertical sleeve gastrectomy improves social behaviors in obese, male mice

Anne Marie Neumann, Cathleen Geißler, Randy Seeley, Henriette Kirchner, Henrik Oster^*

^*Corresponding author for this work

University of Michigan

Abstract

Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.

Original language	English
Journal	Obesity Research and Clinical Practice
Volume	19
Issue number	1
Pages (from-to)	80-83
Number of pages	4
ISSN	1871-403X
DOIs	https://doi.org/10.1016/j.orcp.2025.02.003
Publication status	Published - 01.01.2025

Funding

Funders	Funder number
Deutsche Forschungsgemeinschaft	KI1887/2-1, OS353/10-1, GRK-1957

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
Research Area: Medical Genetics

DFG Research Classification Scheme

2.22-17 Endocrinology, Diabetology, Metabolism
2.23-04 Cognitive, Systems and Behavioural Neurobiology

KDSF Research Field Classification Scheme

231 - Cells and Genes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.orcp.2025.02.003

Cite this

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title = "Vertical sleeve gastrectomy improves social behaviors in obese, male mice",

abstract = "Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.",

author = "Neumann, \{Anne Marie\} and Cathleen Gei{\ss}ler and Randy Seeley and Henriette Kirchner and Henrik Oster",

note = "Publisher Copyright: {\textcopyright} 2025 Asia Oceania Association for the Study of Obesity",

year = "2025",

month = jan,

day = "1",

doi = "10.1016/j.orcp.2025.02.003",

language = "English",

volume = "19",

pages = "80--83",

journal = "Obesity Research and Clinical Practice",

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TY - JOUR

T1 - Vertical sleeve gastrectomy improves social behaviors in obese, male mice

AU - Neumann, Anne Marie

AU - Geißler, Cathleen

AU - Seeley, Randy

AU - Kirchner, Henriette

AU - Oster, Henrik

PY - 2025/1/1

Y1 - 2025/1/1

N2 - Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.

AB - Bariatric surgery is an effective intervention to treat excess weight and deteriorated metabolic health. A majority of patients further benefit from improvements of mental health and the psychosocial state. However, given the complex interplay of factors affecting sociability in humans, the corresponding effects of the surgery remain unclear. In this study, we investigated the effects of vertical sleeve gastrectomy (VSG) on sociability and social interaction in male, obese mice. Results showed an increase in time spent in the social chamber 9 and 30-35 days post-surgery as well as increased interaction with a subject at 9 days post-surgery. The initial enhancement in social behavior was associated with rapid weight loss, but long-term effects persisted beyond this phase when weight was largely recovered. The findings suggest that VSG positively influences sociability, potentially through mechanisms involving the HPA axis, as previously reported. This study provides new insights into the psychosocial benefits of bariatric surgery.

UR - https://www.scopus.com/pages/publications/85217952371

U2 - 10.1016/j.orcp.2025.02.003

DO - 10.1016/j.orcp.2025.02.003

M3 - Letters

C2 - 39955160

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SN - 1871-403X

VL - 19

SP - 80

EP - 83

JO - Obesity Research and Clinical Practice

JF - Obesity Research and Clinical Practice

IS - 1

ER -

Vertical sleeve gastrectomy improves social behaviors in obese, male mice

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

KDSF Research Field Classification Scheme

UN SDGs

Access to Document

Other files and links

Fingerprint

CRC/TRR 296 LocoTact: Local control of TH action

Cite this

Vertical sleeve gastrectomy improves social behaviors in obese, male mice

Abstract

Funding

Research Areas and Centers

DFG Research Classification Scheme

KDSF Research Field Classification Scheme

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

CRC/TRR 296 LocoTact: Local control of TH action

Cite this