@article{dec31f7b09e049699e791780f2876306,
title = "Ver{\"a}nderungen der quervernetzungen im kollagenen bindegewebe bei dermatoliposklerose",
abstract = "Aim: Lipodermotosclerosis in the context of chronic venous insufficiency is characterized by an accumulation of collagen and an increase of trifunctional collagen cross-links typical for skeletal tissues. In the study presented here, the question is answered, whether this increase is due to an increase of all collagen cross-links or whether it is an isolated process. Method: Skin biopsies from 15 patients with lipodermatosclerosis and venous leg ulcer were analysed. The concentration of hydroxylysine- and lysine-derived di- and trifunctional crosslinks were analysed after hydrolysis of the specimens by amino acid analysis. Results: The concentration of hydroxylysine-derived collagen crosslinks showed a marked increase. In contrary, the concentration of total lysine-derived crosslinks decreased significantly. Conclusion: Lipodermatosclerosis is marked by a characteristic change of collagen crosslinks leading to the majority of skeletal-type crosslinks in the skin.",
author = "Yvonne Gaber and K. Tiedemann and Reinhard, \{D. P.\} and J. Brinckmann",
year = "2004",
month = feb,
day = "1",
language = "Deutsch",
volume = "33",
pages = "8--11",
journal = "Phlebologie",
issn = "0939-978X",
publisher = "Georg Thieme Verlag",
number = "1",
}
