TY - JOUR
T1 - Vascular endothelial growth factor in exercising humans under different environmental conditions
AU - Gunga, Hanns Christian
AU - Kirsch, Karl
AU - Röcker, Lothar
AU - Behn, Claus
AU - Koralewski, Eberhard
AU - Davila, Eliseo Hibert
AU - Estrada, Manuel Ivan
AU - Johannes, Bernd
AU - Wittels, Peter
AU - Jelkmann, Wolfgang
N1 - Funding Information:
Ackknowledgements We would like to thank all the subjects, and in addition Mrs. Brigitte Bünsch and Hans Jürgen Wicke for their technical assistance. This research was supported by the following grants: no. 50 WB 93773 and 50WB396462 from the Bun-desministerium für Forschung und Technologie (BMFT), Deutsche Agentur für Raumfahrtangelegenheiten (DARA), no. 1950454 from FONDECYT (Chile), and the Deutscher Akademischer Austauschdienst (DAAD).
Copyright:
Copyright 2007 Elsevier B.V., All rights reserved.
PY - 1999/5
Y1 - 1999/5
N2 - It was the aim of this study to investigate the time course of changes in the serum concentrations of vascular endothelial growth factor (VEGF) during a regular survival training programme combined with food and fluid deprivation and during a high altitude marathon run. We studied soldiers of the Austrian Special Forces performing survival training at sea-level and marathon runners of the Posta Atletica who crossed the border between Chile and Argentina at altitudes up to 4722 m. Baseline data collected before the 1-week of survival training showed that the soldiers had normal VEGF [n = 8, 246.7 (SD 118.5) pg·ml-1] serum concentrations which remained unchanged during the course of the study. Before the high altitude marathon the subjects showed normal VEGF serum concentrations [178 (SD 84.5) pg.ml-1]. After the run VEGF concentrations were found to be significantly decreased [41.0 (SD 41.6) pg·ml-1, P < 0.01]. It was concluded that prolonged physical stress during normobaric-normoxia did not alter the VEGF concentrations whereas during severe hypobaric-hypoxia decreased VEGF serum concentrations were measured, at least temporarily, after prolonged physical exercise which might have been due to changes in production, release, removal and/or binding of circulating VEGF.
AB - It was the aim of this study to investigate the time course of changes in the serum concentrations of vascular endothelial growth factor (VEGF) during a regular survival training programme combined with food and fluid deprivation and during a high altitude marathon run. We studied soldiers of the Austrian Special Forces performing survival training at sea-level and marathon runners of the Posta Atletica who crossed the border between Chile and Argentina at altitudes up to 4722 m. Baseline data collected before the 1-week of survival training showed that the soldiers had normal VEGF [n = 8, 246.7 (SD 118.5) pg·ml-1] serum concentrations which remained unchanged during the course of the study. Before the high altitude marathon the subjects showed normal VEGF serum concentrations [178 (SD 84.5) pg.ml-1]. After the run VEGF concentrations were found to be significantly decreased [41.0 (SD 41.6) pg·ml-1, P < 0.01]. It was concluded that prolonged physical stress during normobaric-normoxia did not alter the VEGF concentrations whereas during severe hypobaric-hypoxia decreased VEGF serum concentrations were measured, at least temporarily, after prolonged physical exercise which might have been due to changes in production, release, removal and/or binding of circulating VEGF.
UR - http://www.scopus.com/inward/record.url?scp=0032926556&partnerID=8YFLogxK
U2 - 10.1007/s004210050541
DO - 10.1007/s004210050541
M3 - Journal articles
C2 - 10344456
AN - SCOPUS:0032926556
SN - 0301-5548
VL - 79
SP - 484
EP - 490
JO - European Journal of Applied Physiology and Occupational Physiology
JF - European Journal of Applied Physiology and Occupational Physiology
IS - 6
ER -
