TY - JOUR
T1 - Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort
AU - ALLIANCE Study Group as part of the German Center for Lung Research (DZL)
AU - Grychtol, Ruth
AU - Riemann, Lennart
AU - Gaedcke, Svenja
AU - Liu, Bin
AU - DeLuca, David
AU - Förster, Reinhold
AU - Maison, Nicole
AU - Thiele, Dominik
AU - Jakobs, Nikolas
AU - Bahmer, Thomas
AU - Meyer, Meike
AU - Foth, Svenja
AU - Weber, Stefanie
AU - Rietschel, Ernst
AU - Rabe, Klaus F.
AU - Kopp, Matthias V.
AU - von Mutius, Erika
AU - Dittrich, Anna Maria
AU - Hansen, Gesine
AU - Fuchs, Oliver
AU - Roesler, Barbara
AU - Welchering, Nils
AU - Kohistani-Greif, Naschla
AU - Kurz, Johanna
AU - Landgraf-Rauf, Katja
AU - Laubhahn, Kristina
AU - Liebl, Claudia
AU - Schaub, Bianca
AU - Ege, Markus
AU - Illi, Sabina
AU - Hose, Alexander
AU - Zeitlmann, Esther
AU - Berbig, Mira
AU - Marzi, Carola
AU - Schauberger, Christina
AU - Zissler, Ulrich
AU - Schmidt-Weber, Carsten
AU - Ricklefs, Isabell
AU - Diekmann, Gesa
AU - Liboschik, Lena
AU - Voigt, Gesche
AU - Sultansei, Laila
AU - Weckmann, Markus
AU - Nissen, Gyde
AU - König, Inke R.
AU - Kirsten, Anne Marie
AU - Bovermann, Xenia
AU - Steinmetz, Alena
AU - Husstedt, Berrit Liselotte
AU - Nitsche, Catharina
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/6
Y1 - 2023/6
N2 - Background: The Asthma Severity Scoring System (ASSESS) quantifies asthma severity in adolescents and adults. Scale performance in children younger than 12 years is unknown. Objective: To validate the ASSESS score in the All Age Asthma Cohort and explore its use in children younger than 12 years. Methods: Scale properties, responsiveness, and known-group validity were assessed in 247 children (median age, 11 years; interquartile range, 8-13 years) and 206 adults (median age, 52 years; interquartile range, 43-63 years). Results: Overall, measures of internal test consistency and test-retest reliability were similar to the original data of the Severe Asthma Research Program. Cronbach α was 0.59 in children aged 12 to 18 years and 0.73 in adults, reflecting the inclusion of multiple and not-always congruent dimensions to the ASSESS score, especially in children. Analysis of known-group validity confirmed the discriminatory power, because the ASSESS score was significantly worse in patients with poor asthma control, exacerbations, and increased salbutamol use. In children aged 6 to 11 years, test-retest reliability was inferior compared with that in adults and adolescents (Cronbach α, 0.27) mostly because of a less lung function impairment in children with asthma of this age group. Known-group validity, however, confirmed good discriminative power regarding severity-associated variables similar to adolescents and adults. Conclusions: Test-retest reliability and validity of the ASSESS score was confirmed in the All Age Asthma Cohort. In children aged 6 to 11 years, internal consistency was inferior compared with that in older patients with asthma; however, test validity was good and thus encourages age-spanning usage of the ASSESS score in all patients 6 years or older.
AB - Background: The Asthma Severity Scoring System (ASSESS) quantifies asthma severity in adolescents and adults. Scale performance in children younger than 12 years is unknown. Objective: To validate the ASSESS score in the All Age Asthma Cohort and explore its use in children younger than 12 years. Methods: Scale properties, responsiveness, and known-group validity were assessed in 247 children (median age, 11 years; interquartile range, 8-13 years) and 206 adults (median age, 52 years; interquartile range, 43-63 years). Results: Overall, measures of internal test consistency and test-retest reliability were similar to the original data of the Severe Asthma Research Program. Cronbach α was 0.59 in children aged 12 to 18 years and 0.73 in adults, reflecting the inclusion of multiple and not-always congruent dimensions to the ASSESS score, especially in children. Analysis of known-group validity confirmed the discriminatory power, because the ASSESS score was significantly worse in patients with poor asthma control, exacerbations, and increased salbutamol use. In children aged 6 to 11 years, test-retest reliability was inferior compared with that in adults and adolescents (Cronbach α, 0.27) mostly because of a less lung function impairment in children with asthma of this age group. Known-group validity, however, confirmed good discriminative power regarding severity-associated variables similar to adolescents and adults. Conclusions: Test-retest reliability and validity of the ASSESS score was confirmed in the All Age Asthma Cohort. In children aged 6 to 11 years, internal consistency was inferior compared with that in older patients with asthma; however, test validity was good and thus encourages age-spanning usage of the ASSESS score in all patients 6 years or older.
UR - http://www.scopus.com/inward/record.url?scp=85160079482&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2023.01.027
DO - 10.1016/j.jaci.2023.01.027
M3 - Journal articles
C2 - 36804993
AN - SCOPUS:85160079482
SN - 0091-6749
VL - 151
SP - 1525-1535.e4
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
IS - 6
ER -
