Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: Results of the German IGLU follow-up study 2001

Helmuth G. Doerr; M. Bettendorf; B. P. Hauffa; Otto Mehls; C. J. Partsch; Elfriede Said; Sabine Sander; H. P. Schwarz; N. Stahnke; Heiner Steinkamp; Michael B. Ranke; H. I. Akkurt; W. Andler; M. Becker; H. J. Böhles; J. Brämswig; O. Butenandt; M. Bettendorf; H. G. Doerr; J. H.H. Ehrich; B. Erxleben; B. Griefahn; A. Grueters; K. Hartmann; B. P. Hauffa; F. Haverkamp; W. Hecker; U. Heinrich; G. K. Hinkel; O. Hiort; R. Holl; J. Homoki; G. Horneff; U. Irle; R. Johs; C. Jourdan; E. Keller; J. Kerstan; E. Korsch; J. Kreuder; H. P. Krohn; F. Krull; D. Kunze; M. Lakomek; D. Lenz; U. Leuthold; M. Mix; K. Mohnike; M. Morlot; R. Mühlenberg; H. Müller; C. J. Partsch; M. Pavlovic; K. Rager; M. B. Ranke; W. Rauh; H. J. Rickers; B. Schenk; D. Schnabel; E. Schönau; H. P. Schwarz; G. Skimic-Schleicher; W. G. Sippell; N. Stahnke; M. Teufel; W. Tillmann; B. Tittel; U. Tuschy; K. P. Ullrich; W. von Petrikowsky; H. P. Weber; K. Wesseler; R. P. Willig; J. Wintgens; M. Witsch

doi:10.1093/humrep/deh764

Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: Results of the German IGLU follow-up study 2001

Helmuth G. Doerr, M. Bettendorf, B. P. Hauffa, Otto Mehls, C. J. Partsch, Elfriede Said, Sabine Sander, H. P. Schwarz, N. Stahnke, Heiner Steinkamp, Michael B. Ranke, H. I. Akkurt, W. Andler, M. Becker, H. J. Böhles, J. Brämswig, O. Butenandt, M. Bettendorf, H. G. Doerr, J. H.H. EhrichB. Erxleben, B. Griefahn, A. Grueters, K. Hartmann, B. P. Hauffa, F. Haverkamp, W. Hecker, U. Heinrich, G. K. Hinkel, O. Hiort, R. Holl, J. Homoki, G. Horneff, U. Irle, R. Johs, C. Jourdan, E. Keller, J. Kerstan, E. Korsch, J. Kreuder, H. P. Krohn, F. Krull, D. Kunze, M. Lakomek, D. Lenz, U. Leuthold, M. Mix, K. Mohnike, M. Morlot, R. Mühlenberg, H. Müller, C. J. Partsch, M. Pavlovic, K. Rager, M. B. Ranke, W. Rauh, H. J. Rickers, B. Schenk, D. Schnabel, E. Schönau, H. P. Schwarz, G. Skimic-Schleicher, W. G. Sippell, N. Stahnke, M. Teufel, W. Tillmann, B. Tittel, U. Tuschy, K. P. Ullrich, W. von Petrikowsky, H. P. Weber, K. Wesseler, R. P. Willig, J. Wintgens, M. Witsch

Clinic of Pediatric and Adolescent Medicine

42 Citations (Scopus)

Abstract

Background: To evaluate the factors influencing uterine size in young adult women with Turner syndrome (TS) after long-term growth hormone (GH) treatment. Methods: Cross-sectional study. Out of 188 women with TS from 96 German centres, whose longitudinal growth was documented within KIGS (Pfizer International Growth Database), data on uterine size were collected voluntarily at a standardized follow-up visit: 75 TS women (ages: 15.8-30.8 years) with complete data were included. Classification according to karyotype: 45,X (78.6%), 45,X/46,XX (5.4%), 45,X/46,iXq (8%), 45,X/46,XY (8%). Puberty was induced with estrogens in all women. At follow-up, 66 were on cyclic estrogens and progestins. Results: 13/66 (19.6%) TS women who received estrogens had a reduced uterine length <5cm. Calculating the data in standard deviation scores (SDS), only women with 45,X/46,XX karyotype had normal median uterine length and volume of 0.6 and 1.59 SDS respectively. An incomplete breast development (Tanner stage B 3) was found in women with 45,X karyotype (n = 11; 18.6%) and with 45,X/46,XY (n = 2). Conclusions: Only TS women with karyotype 45,X/46,XX had normal uterine sizes, whereas 26% of the TS women with karyotype 45,X had a uterine length <-2 SDS, and 18% a volume <-2 SDS.

Original language	English
Journal	Human Reproduction
Volume	20
Issue number	5
Pages (from-to)	1418-1421
Number of pages	4
ISSN	0268-1161
DOIs	https://doi.org/10.1093/humrep/deh764
Publication status	Published - 05.2005

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Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1093/humrep/deh764

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Doerr, H. G., Bettendorf, M., Hauffa, B. P., Mehls, O., Partsch, C. J., Said, E., Sander, S., Schwarz, H. P., Stahnke, N., Steinkamp, H., Ranke, M. B., Akkurt, H. I., Andler, W., Becker, M., Böhles, H. J., Brämswig, J., Butenandt, O., Bettendorf, M., Doerr, H. G., ... Witsch, M. (2005). Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: Results of the German IGLU follow-up study 2001. Human Reproduction, 20(5), 1418-1421. https://doi.org/10.1093/humrep/deh764

@article{0ce030c2213a438b9f32e9137450292c,

title = "Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: Results of the German IGLU follow-up study 2001",

abstract = "Background: To evaluate the factors influencing uterine size in young adult women with Turner syndrome (TS) after long-term growth hormone (GH) treatment. Methods: Cross-sectional study. Out of 188 women with TS from 96 German centres, whose longitudinal growth was documented within KIGS (Pfizer International Growth Database), data on uterine size were collected voluntarily at a standardized follow-up visit: 75 TS women (ages: 15.8-30.8 years) with complete data were included. Classification according to karyotype: 45,X (78.6%), 45,X/46,XX (5.4%), 45,X/46,iXq (8%), 45,X/46,XY (8%). Puberty was induced with estrogens in all women. At follow-up, 66 were on cyclic estrogens and progestins. Results: 13/66 (19.6%) TS women who received estrogens had a reduced uterine length <5cm. Calculating the data in standard deviation scores (SDS), only women with 45,X/46,XX karyotype had normal median uterine length and volume of 0.6 and 1.59 SDS respectively. An incomplete breast development (Tanner stage B 3) was found in women with 45,X karyotype (n = 11; 18.6%) and with 45,X/46,XY (n = 2). Conclusions: Only TS women with karyotype 45,X/46,XX had normal uterine sizes, whereas 26% of the TS women with karyotype 45,X had a uterine length <-2 SDS, and 18% a volume <-2 SDS.",

author = "Doerr, {Helmuth G.} and M. Bettendorf and Hauffa, {B. P.} and Otto Mehls and Partsch, {C. J.} and Elfriede Said and Sabine Sander and Schwarz, {H. P.} and N. Stahnke and Heiner Steinkamp and Ranke, {Michael B.} and Akkurt, {H. I.} and W. Andler and M. Becker and B{\"o}hles, {H. J.} and J. Br{\"a}mswig and O. Butenandt and M. Bettendorf and Doerr, {H. G.} and Ehrich, {J. H.H.} and B. Erxleben and B. Griefahn and A. Grueters and K. Hartmann and Hauffa, {B. P.} and F. Haverkamp and W. Hecker and U. Heinrich and Hinkel, {G. K.} and O. Hiort and R. Holl and J. Homoki and G. Horneff and U. Irle and R. Johs and C. Jourdan and E. Keller and J. Kerstan and E. Korsch and J. Kreuder and Krohn, {H. P.} and F. Krull and D. Kunze and M. Lakomek and D. Lenz and U. Leuthold and M. Mix and K. Mohnike and M. Morlot and R. M{\"u}hlenberg and H. M{\"u}ller and Partsch, {C. J.} and M. Pavlovic and K. Rager and Ranke, {M. B.} and W. Rauh and Rickers, {H. J.} and B. Schenk and D. Schnabel and E. Sch{\"o}nau and Schwarz, {H. P.} and G. Skimic-Schleicher and Sippell, {W. G.} and N. Stahnke and M. Teufel and W. Tillmann and B. Tittel and U. Tuschy and Ullrich, {K. P.} and {von Petrikowsky}, W. and Weber, {H. P.} and K. Wesseler and Willig, {R. P.} and J. Wintgens and M. Witsch",

year = "2005",

month = may,

doi = "10.1093/humrep/deh764",

language = "English",

volume = "20",

pages = "1418--1421",

journal = "Human Reproduction",

issn = "0268-1161",

number = "5",

}

Doerr, HG, Bettendorf, M, Hauffa, BP, Mehls, O, Partsch, CJ, Said, E, Sander, S, Schwarz, HP, Stahnke, N, Steinkamp, H, Ranke, MB, Akkurt, HI, Andler, W, Becker, M, Böhles, HJ, Brämswig, J, Butenandt, O, Bettendorf, M, Doerr, HG, Ehrich, JHH, Erxleben, B, Griefahn, B, Grueters, A, Hartmann, K, Hauffa, BP, Haverkamp, F, Hecker, W, Heinrich, U, Hinkel, GK, Hiort, O, Holl, R, Homoki, J, Horneff, G, Irle, U, Johs, R, Jourdan, C, Keller, E, Kerstan, J, Korsch, E, Kreuder, J, Krohn, HP, Krull, F, Kunze, D, Lakomek, M, Lenz, D, Leuthold, U, Mix, M, Mohnike, K, Morlot, M, Mühlenberg, R, Müller, H, Partsch, CJ, Pavlovic, M, Rager, K, Ranke, MB, Rauh, W, Rickers, HJ, Schenk, B, Schnabel, D, Schönau, E, Schwarz, HP, Skimic-Schleicher, G, Sippell, WG, Stahnke, N, Teufel, M, Tillmann, W, Tittel, B, Tuschy, U, Ullrich, KP, von Petrikowsky, W, Weber, HP, Wesseler, K, Willig, RP, Wintgens, J & Witsch, M 2005, 'Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: Results of the German IGLU follow-up study 2001', Human Reproduction, vol. 20, no. 5, pp. 1418-1421. https://doi.org/10.1093/humrep/deh764

Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: Results of the German IGLU follow-up study 2001. / Doerr, Helmuth G.; Bettendorf, M.; Hauffa, B. P. et al.
In: Human Reproduction, Vol. 20, No. 5, 05.2005, p. 1418-1421.

Research output: Journal Articles › Journal articles › Research › peer-review

TY - JOUR

T1 - Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: Results of the German IGLU follow-up study 2001

AU - Doerr, Helmuth G.

AU - Bettendorf, M.

AU - Hauffa, B. P.

AU - Mehls, Otto

AU - Partsch, C. J.

AU - Said, Elfriede

AU - Sander, Sabine

AU - Schwarz, H. P.

AU - Stahnke, N.

AU - Steinkamp, Heiner

AU - Ranke, Michael B.

AU - Akkurt, H. I.

AU - Andler, W.

AU - Becker, M.

AU - Böhles, H. J.

AU - Brämswig, J.

AU - Butenandt, O.

AU - Bettendorf, M.

AU - Doerr, H. G.

AU - Ehrich, J. H.H.

AU - Erxleben, B.

AU - Griefahn, B.

AU - Grueters, A.

AU - Hartmann, K.

AU - Hauffa, B. P.

AU - Haverkamp, F.

AU - Hecker, W.

AU - Heinrich, U.

AU - Hinkel, G. K.

AU - Hiort, O.

AU - Holl, R.

AU - Homoki, J.

AU - Horneff, G.

AU - Irle, U.

AU - Johs, R.

AU - Jourdan, C.

AU - Keller, E.

AU - Kerstan, J.

AU - Korsch, E.

AU - Kreuder, J.

AU - Krohn, H. P.

AU - Krull, F.

AU - Kunze, D.

AU - Lakomek, M.

AU - Lenz, D.

AU - Leuthold, U.

AU - Mix, M.

AU - Mohnike, K.

AU - Morlot, M.

AU - Mühlenberg, R.

AU - Müller, H.

AU - Partsch, C. J.

AU - Pavlovic, M.

AU - Rager, K.

AU - Ranke, M. B.

AU - Rauh, W.

AU - Rickers, H. J.

AU - Schenk, B.

AU - Schnabel, D.

AU - Schönau, E.

AU - Schwarz, H. P.

AU - Skimic-Schleicher, G.

AU - Sippell, W. G.

AU - Stahnke, N.

AU - Teufel, M.

AU - Tillmann, W.

AU - Tittel, B.

AU - Tuschy, U.

AU - Ullrich, K. P.

AU - von Petrikowsky, W.

AU - Weber, H. P.

AU - Wesseler, K.

AU - Willig, R. P.

AU - Wintgens, J.

AU - Witsch, M.

PY - 2005/5

Y1 - 2005/5

N2 - Background: To evaluate the factors influencing uterine size in young adult women with Turner syndrome (TS) after long-term growth hormone (GH) treatment. Methods: Cross-sectional study. Out of 188 women with TS from 96 German centres, whose longitudinal growth was documented within KIGS (Pfizer International Growth Database), data on uterine size were collected voluntarily at a standardized follow-up visit: 75 TS women (ages: 15.8-30.8 years) with complete data were included. Classification according to karyotype: 45,X (78.6%), 45,X/46,XX (5.4%), 45,X/46,iXq (8%), 45,X/46,XY (8%). Puberty was induced with estrogens in all women. At follow-up, 66 were on cyclic estrogens and progestins. Results: 13/66 (19.6%) TS women who received estrogens had a reduced uterine length <5cm. Calculating the data in standard deviation scores (SDS), only women with 45,X/46,XX karyotype had normal median uterine length and volume of 0.6 and 1.59 SDS respectively. An incomplete breast development (Tanner stage B 3) was found in women with 45,X karyotype (n = 11; 18.6%) and with 45,X/46,XY (n = 2). Conclusions: Only TS women with karyotype 45,X/46,XX had normal uterine sizes, whereas 26% of the TS women with karyotype 45,X had a uterine length <-2 SDS, and 18% a volume <-2 SDS.

AB - Background: To evaluate the factors influencing uterine size in young adult women with Turner syndrome (TS) after long-term growth hormone (GH) treatment. Methods: Cross-sectional study. Out of 188 women with TS from 96 German centres, whose longitudinal growth was documented within KIGS (Pfizer International Growth Database), data on uterine size were collected voluntarily at a standardized follow-up visit: 75 TS women (ages: 15.8-30.8 years) with complete data were included. Classification according to karyotype: 45,X (78.6%), 45,X/46,XX (5.4%), 45,X/46,iXq (8%), 45,X/46,XY (8%). Puberty was induced with estrogens in all women. At follow-up, 66 were on cyclic estrogens and progestins. Results: 13/66 (19.6%) TS women who received estrogens had a reduced uterine length <5cm. Calculating the data in standard deviation scores (SDS), only women with 45,X/46,XX karyotype had normal median uterine length and volume of 0.6 and 1.59 SDS respectively. An incomplete breast development (Tanner stage B 3) was found in women with 45,X karyotype (n = 11; 18.6%) and with 45,X/46,XY (n = 2). Conclusions: Only TS women with karyotype 45,X/46,XX had normal uterine sizes, whereas 26% of the TS women with karyotype 45,X had a uterine length <-2 SDS, and 18% a volume <-2 SDS.

UR - http://www.scopus.com/inward/record.url?scp=20344380670&partnerID=8YFLogxK

U2 - 10.1093/humrep/deh764

DO - 10.1093/humrep/deh764

M3 - Journal articles

C2 - 15695313

AN - SCOPUS:20344380670

SN - 0268-1161

VL - 20

SP - 1418

EP - 1421

JO - Human Reproduction

JF - Human Reproduction

IS - 5

ER -

Uterine size in women with Turner syndrome after induction of puberty with estrogens and long-term growth hormone therapy: Results of the German IGLU follow-up study 2001

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