Update Granulomatose mit Polyangiitis (GPA, Wegener-Granulomatose)

Translated title of the contribution: Update on granulomatosis with polyangitis (GPA, Wegener's granulomatosis)

J. U. Holle*, E. Reinhold-Keller, W. L. Gross

*Corresponding author for this work
3 Citations (Scopus)


Granulomatosis with polyangitis (GPA, Wegener's granulomatosis) is characterized by a granulomatous inflammation of the respiratory tract and a necrotizing ANCA-associated small to medium-size vessel vasculitis with a predilection for the lungs (pulmonary capillaritis) and kidneys (necrotizing glomerulonephritis). The disease evolves stage-wise and typically starts as inflammation of the respiratory tract followed by development of systemic vasculitis manifestations. Today, treatment is evidence-based and adapted according to activity and disease stage which has resulted in a significant improvement in long-term outcome. Early mortality during the first year of treatment poses one of the main problems and is a result of infections under immunosuppressive treatment. Furthermore, treatment of refractory disease activity which is often represented by granulomatous manifestations is still a challenge and may result in significant organ damage if not treated successfully.

Translated title of the contributionUpdate on granulomatosis with polyangitis (GPA, Wegener's granulomatosis)
Original languageGerman
JournalZeitschrift fur Rheumatologie
Issue number9
Pages (from-to)745-753
Number of pages9
Publication statusPublished - 11.2012

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)


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