Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle

Jan Philip Kolb; Thomas Klein; Corinna L. Kufner; Wolfgang Wieser; Aljoscha S. Neubauer; Robert Huber

doi:10.1364/BOE.6.001534

Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle

Jan Philip Kolb, Thomas Klein, Corinna L. Kufner, Wolfgang Wieser, Aljoscha S. Neubauer, Robert Huber^*

^*Corresponding author for this work

Institute of Biomedical Optics

41 Citations (Scopus)

Abstract

We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes. Three imaging modes are tested: Single volume imaging with 85° FOV as well as with 100° and stitching of five 60° images to a 100° mosaic (measured from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate of 1.68MHz. The high speed is essential for dense isotropic sampling of the large areas. Challenges caused by the wide FOV are discussed and solutions to most issues are presented. Detailed information on the design and characterization of our sample arm optics is given. We investigate the origin of an angle dependent signal fall-off which we observe towards larger imaging angles. It is present in our 85° and 100° single volume images, but not in the mosaic. Our results suggest that 100° FOV OCT is possible with current swept source OCT technology.

Original language	English
Article number	A001
Journal	Biomedical Optics Express
Volume	6
Issue number	5
Pages (from-to)	1534-1552
Number of pages	19
DOIs	https://doi.org/10.1364/BOE.6.001534
Publication status	Published - 02.04.2015

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abstract = "We evaluate strategies to maximize the field of view (FOV) of in vivo retinal OCT imaging of human eyes. Three imaging modes are tested: Single volume imaging with 85° FOV as well as with 100° and stitching of five 60° images to a 100° mosaic (measured from the nodal point). We employ a MHz-OCT system based on a 1060nm Fourier domain mode locked (FDML) laser with a depth scan rate of 1.68MHz. The high speed is essential for dense isotropic sampling of the large areas. Challenges caused by the wide FOV are discussed and solutions to most issues are presented. Detailed information on the design and characterization of our sample arm optics is given. We investigate the origin of an angle dependent signal fall-off which we observe towards larger imaging angles. It is present in our 85° and 100° single volume images, but not in the mosaic. Our results suggest that 100° FOV OCT is possible with current swept source OCT technology.",

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AU - Neubauer, Aljoscha S.

AU - Huber, Robert

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Ultra-widefield retinal MHz-OCT imaging with up to 100 degrees viewing angle

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