Abstract
Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.
| Original language | English |
|---|---|
| Journal | European Journal of Pediatrics |
| Volume | 179 |
| Issue number | 8 |
| Pages (from-to) | 1309-1313 |
| Number of pages | 5 |
| ISSN | 0340-6199 |
| DOIs | |
| Publication status | Published - 01.08.2020 |
Funding
We are grateful for the support of the families and of the colleagues contributing to this network. Egbert Herting, Angela Kribs, Christoph H?rtel, Bernhard Roth and Wolfgang G?pel designed the AMV study originally. Egbert Herting, Angela Kribs, Christoph H?rtel, Axel von der Wense, Ursula Weller, Thomas Hoehn, Matthias Vochem, Jens M?ller, Christian Wieg, Bernhard Roth and Wolfgang G?pel were actively involved in the data collection for the follow-up at 2?years. The first draft of the manuscript was written by Egbert Herting and Wolfgang G?pel. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
