TY - JOUR
T1 - Two-year outcome data suggest that less invasive surfactant administration (LISA) is safe. Results from the follow-up of the randomized controlled AMV (avoid mechanical ventilation) study
AU - for the German Neonatal Network (GNN)
AU - Herting, Egbert
AU - Kribs, Angela
AU - Härtel, Christoph
AU - von der Wense, Axel
AU - Weller, Ursula
AU - Hoehn, Thomas
AU - Vochem, Matthias
AU - Möller, Jens
AU - Wieg, Christian
AU - Roth, Bernhard
AU - Göpel, Wolfgang
N1 - Funding Information:
We are grateful for the support of the families and of the colleagues contributing to this network. Egbert Herting, Angela Kribs, Christoph H?rtel, Bernhard Roth and Wolfgang G?pel designed the AMV study originally. Egbert Herting, Angela Kribs, Christoph H?rtel, Axel von der Wense, Ursula Weller, Thomas Hoehn, Matthias Vochem, Jens M?ller, Christian Wieg, Bernhard Roth and Wolfgang G?pel were actively involved in the data collection for the follow-up at 2?years. The first draft of the manuscript was written by Egbert Herting and Wolfgang G?pel. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
Publisher Copyright:
© 2020, The Author(s).
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/8/1
Y1 - 2020/8/1
N2 - Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.
AB - Less invasive surfactant administration (LISA) is a method to deliver surfactant to spontaneously breathing premature infants via a thin catheter. Here we report the two-year outcome from the AMV (avoid mechanical ventilation) study, the first randomized controlled trial on this mode of surfactant delivery. No statistically significant differences in weight, length or neurodevelopmental outcome (Bayley II scores) were found between the LISA intervention group (n = 95) and the control group (n = 84) that received standard treatment. Conclusion: No differences in outcome were observed at 2 years. LISA seems safe in that aspect.What is Known:• LISA is a method that is in increasing use for surfactant delivery to spontaneously breathing infants. LISA reduces the need for mechanical ventilation.What is New:• Outcome data at 2 years from the first randomized study with LISA raise no safety concerns in comparison to a group of infants that received standard treatment.
UR - http://www.scopus.com/inward/record.url?scp=85079719058&partnerID=8YFLogxK
U2 - 10.1007/s00431-020-03572-0
DO - 10.1007/s00431-020-03572-0
M3 - Journal articles
C2 - 32067100
AN - SCOPUS:85079719058
SN - 0340-6199
VL - 179
SP - 1309
EP - 1313
JO - European Journal of Pediatrics
JF - European Journal of Pediatrics
IS - 8
ER -
