TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia

TRIMAGE Consortium

doi:10.1016/j.eurpsy.2017.11.007

TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia

TRIMAGE Consortium

Clinic of Psychiatry and Psychotherapy

44 Citations (Scopus)

Abstract

Simultaneous PET/MR/EEG (Positron Emission Tomography – Magnetic Resonance – Electroencephalography), a new tool for the investigation of neuronal networks in the human brain, is presented here within the framework of the European Union Project TRIMAGE. The trimodal, cost-effective PET/MR/EEG imaging tool makes use of cutting edge technology both in PET and in MR fields. A novel type of magnet (1.5T, non-cryogenic) has been built together with a PET scanner that makes use of the most advanced photodetectors (i.e., SiPM matrices), scintillators matrices (LYSO) and digital electronics. The combined PET/MR/EEG system is dedicated to brain imaging and has an inner diameter of 260 mm and an axial Field-of-View of 160 mm. It enables the acquisition and assessment of molecular metabolic information with high spatial and temporal resolution in a given brain simultaneously. The dopaminergic system and the glutamatergic system in schizophrenic patients are investigated via PET, the same physiological/pathophysiological conditions with regard to functional connectivity, via fMRI, and its electrophysiological signature via EEG. In addition to basic neuroscience questions addressing neurovascular-metabolic coupling, this new methodology lays the foundation for individual physiological and pathological fingerprints for a wide research field addressing healthy aging, gender effects, plasticity and different psychiatric and neurological diseases. The preliminary performances of two components of the imaging tool (PET and MR) are discussed. Initial results of the search of possible candidates for suitable schizophrenia biomarkers are also presented as obtained with PET/MR systems available to the collaboration.

Original language	English
Journal	European Psychiatry
Volume	50
Pages (from-to)	7-20
Number of pages	14
ISSN	0924-9338
DOIs	https://doi.org/10.1016/j.eurpsy.2017.11.007
Publication status	Published - 04.2018

Funding

N. Jon Shah is funded in part by the Helmholtz Alliance ICEMED − Imaging and Curing Environmental Metabolic Diseases , through the Initiative and Network Fund of the Helmholtz Association. N. Jon Shah acknowledges funding from the BMBF and Siemens for the 9.4T MR-PET project (Grant number 13N9121 ). N. Jon Shah and Irene Neuner report partial funding from the DFG for the implementation of the trimodal approach (Shah DFG SH 79/2-2 ). Claudia Regio-Brambilla is financed by a DAAD PhD stipend under the joint supervision of Irene Neuner and Christoph Lerche with focus on the ABP688 approach. We thank Suzanne Schaden, Silke Frensch and Cornelia Frey for excellent technical assistance in data acquisition in Jülich. The PET/MR facility at the Technische Universit?t M?nchen was funded by the Deutsche Forschungsgemeinschaft, Gro?ger?teinitiative (DFG). The research leading to these results has received funding from the European Union Seventh Framework Program (FP7) under grant agreement no. 294582 ERC Grant MUMI. The excellent technical assistance of Sylvia Schachoff at TUM is greatly appreciated. The research leading to these results has received funding from the European Union Seventh Framework Programme (FP7/2007-2013) under grant agreement n° 602621- Trimage . The PET/MR facility at the Technische Universität München was funded by the Deutsche Forschungsgemeinschaft, Großgeräteinitiative (DFG) . The research leading to these results has received funding from the European Union Seventh Framework Program (FP7) under grant agreement no. 294582 ERC Grant MUMI. The excellent technical assistance of Sylvia Schachoff at TUM is greatly appreciated.

Funders	Funder number
Helmholtz Association
Helmholtz Alliance ICEMED
Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft
Seventh Framework Programme	602621
European Union Seventh Framework Program
European Research Council
European Commission	294582
Siemens CT	DFG SH 79/2-2, 13N9121

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SDG 3 Good Health and Well-being

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10.1016/j.eurpsy.2017.11.007

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title = "TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia",

abstract = "Simultaneous PET/MR/EEG (Positron Emission Tomography – Magnetic Resonance – Electroencephalography), a new tool for the investigation of neuronal networks in the human brain, is presented here within the framework of the European Union Project TRIMAGE. The trimodal, cost-effective PET/MR/EEG imaging tool makes use of cutting edge technology both in PET and in MR fields. A novel type of magnet (1.5T, non-cryogenic) has been built together with a PET scanner that makes use of the most advanced photodetectors (i.e., SiPM matrices), scintillators matrices (LYSO) and digital electronics. The combined PET/MR/EEG system is dedicated to brain imaging and has an inner diameter of 260 mm and an axial Field-of-View of 160 mm. It enables the acquisition and assessment of molecular metabolic information with high spatial and temporal resolution in a given brain simultaneously. The dopaminergic system and the glutamatergic system in schizophrenic patients are investigated via PET, the same physiological/pathophysiological conditions with regard to functional connectivity, via fMRI, and its electrophysiological signature via EEG. In addition to basic neuroscience questions addressing neurovascular-metabolic coupling, this new methodology lays the foundation for individual physiological and pathological fingerprints for a wide research field addressing healthy aging, gender effects, plasticity and different psychiatric and neurological diseases. The preliminary performances of two components of the imaging tool (PET and MR) are discussed. Initial results of the search of possible candidates for suitable schizophrenia biomarkers are also presented as obtained with PET/MR systems available to the collaboration.",

author = "\{TRIMAGE Consortium\} and \{Del Guerra\}, Alberto and Salleh Ahmad and Mihai Avram and Nicola Belcari and Arne Berneking and Laura Biagi and Bisogni, \{Maria Giuseppina\} and Felix Brandl and Jorge Cabello and Niccol{\`o} Camarlinghi and Piergiorgio Cerello and Choi, \{Chang Hoon\} and Silvia Coli and Sabrina Colpo and Julien Fleury and Vito Gagliardi and Giuseppe Giraudo and Karsten Heekeren and Wolfram Kawohl and Theodora Kostou and Lefaucheur, \{Jean Luc\} and Christoph Lerche and George Loudos and Matteo Morrocchi and Julien Muller and Mona Mustafa and Irene Neuner and Panagiotis Papadimitroulas and Francesco Pennazio and Ravichandran Rajkumar and Brambilla, \{Cl{\'a}udia R{\'e}gio\} and Julien Rivoire and Kops, \{Elena Rota\} and J{\"u}rgen Scheins and R{\'e}my Schimpf and Shah, \{N. Jon\} and Christian Sorg and Giancarlo Sportelli and Michela Tosetti and Riccardo Trinchero and Christine Wyss and Sibylle Ziegler",

note = "Publisher Copyright: {\textcopyright} 2017 Elsevier Masson SAS",

year = "2018",

month = apr,

doi = "10.1016/j.eurpsy.2017.11.007",

language = "English",

volume = "50",

pages = "7--20",

journal = "European Psychiatry",

issn = "0924-9338",

publisher = "Cambridge University Press",

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T2 - A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia

AU - TRIMAGE Consortium

AU - Del Guerra, Alberto

AU - Ahmad, Salleh

AU - Avram, Mihai

AU - Belcari, Nicola

AU - Berneking, Arne

AU - Biagi, Laura

AU - Bisogni, Maria Giuseppina

AU - Brandl, Felix

AU - Cabello, Jorge

AU - Camarlinghi, Niccolò

AU - Cerello, Piergiorgio

AU - Choi, Chang Hoon

AU - Coli, Silvia

AU - Colpo, Sabrina

AU - Fleury, Julien

AU - Gagliardi, Vito

AU - Giraudo, Giuseppe

AU - Heekeren, Karsten

AU - Kawohl, Wolfram

AU - Kostou, Theodora

AU - Lefaucheur, Jean Luc

AU - Lerche, Christoph

AU - Loudos, George

AU - Morrocchi, Matteo

AU - Muller, Julien

AU - Mustafa, Mona

AU - Neuner, Irene

AU - Papadimitroulas, Panagiotis

AU - Pennazio, Francesco

AU - Rajkumar, Ravichandran

AU - Brambilla, Cláudia Régio

AU - Rivoire, Julien

AU - Kops, Elena Rota

AU - Scheins, Jürgen

AU - Schimpf, Rémy

AU - Shah, N. Jon

AU - Sorg, Christian

AU - Sportelli, Giancarlo

AU - Tosetti, Michela

AU - Trinchero, Riccardo

AU - Wyss, Christine

AU - Ziegler, Sibylle

PY - 2018/4

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JO - European Psychiatry

JF - European Psychiatry

ER -

TRIMAGE: A dedicated trimodality (PET/MR/EEG) imaging tool for schizophrenia

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