Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism

S. Paus; F. Gadow; O. Kaut; M. Knapp; C. Klein; T. Klockgether; U. Wüllner

doi:10.1016/j.parkreldis.2010.03.006

Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism

S. Paus^*, F. Gadow, O. Kaut, M. Knapp, C. Klein, T. Klockgether, U. Wüllner

^*Corresponding author for this work

Institute of Neurogenetics

4 Citations (Scopus)

Abstract

A common subset of genetic risk factors for Parkinson's disease (PD) and essential tremor (ET) has been postulated. Recently, an association between the dopamine D₃ receptor (DRD3) Ser9Gly polymorphism and ET has been reported. We studied whether PD tremor is influenced by Ser9Gly in a genetic association study based on the gene bank of the German Competence Network on Parkinson's disease. The study included analyses of motor predominance (mixed, hypokinetic, and tremor), and tremor type (resting, postural, and action). We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype. Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted.

Original language	English
Journal	Parkinsonism and Related Disorders
Volume	16
Issue number	6
Pages (from-to)	381-383
Number of pages	3
ISSN	1353-8020
DOIs	https://doi.org/10.1016/j.parkreldis.2010.03.006
Publication status	Published - 01.07.2010

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title = "Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism",

abstract = "A common subset of genetic risk factors for Parkinson's disease (PD) and essential tremor (ET) has been postulated. Recently, an association between the dopamine D3 receptor (DRD3) Ser9Gly polymorphism and ET has been reported. We studied whether PD tremor is influenced by Ser9Gly in a genetic association study based on the gene bank of the German Competence Network on Parkinson's disease. The study included analyses of motor predominance (mixed, hypokinetic, and tremor), and tremor type (resting, postural, and action). We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype. Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted.",

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T1 - Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism

AU - Paus, S.

AU - Gadow, F.

AU - Kaut, O.

AU - Knapp, M.

AU - Klein, C.

AU - Klockgether, T.

AU - Wüllner, U.

PY - 2010/7/1

Y1 - 2010/7/1

N2 - A common subset of genetic risk factors for Parkinson's disease (PD) and essential tremor (ET) has been postulated. Recently, an association between the dopamine D3 receptor (DRD3) Ser9Gly polymorphism and ET has been reported. We studied whether PD tremor is influenced by Ser9Gly in a genetic association study based on the gene bank of the German Competence Network on Parkinson's disease. The study included analyses of motor predominance (mixed, hypokinetic, and tremor), and tremor type (resting, postural, and action). We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype. Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted.

AB - A common subset of genetic risk factors for Parkinson's disease (PD) and essential tremor (ET) has been postulated. Recently, an association between the dopamine D3 receptor (DRD3) Ser9Gly polymorphism and ET has been reported. We studied whether PD tremor is influenced by Ser9Gly in a genetic association study based on the gene bank of the German Competence Network on Parkinson's disease. The study included analyses of motor predominance (mixed, hypokinetic, and tremor), and tremor type (resting, postural, and action). We did not identify any effect of DRD3 Ser9Gly on tremor in PD, even when regarding various symptom combinations to avoid missing a weak effect on the phenotype. Additional studies incorporating symptoms at disease onset, and grading of tremor response to dopaminergic therapy, are warranted.

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SN - 1353-8020

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EP - 383

JO - Parkinsonism and Related Disorders

JF - Parkinsonism and Related Disorders

IS - 6

ER -

Tremor in Parkinson's disease is not associated with the DRD3 Ser9Gly polymorphism

Abstract

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