Abstract
The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.
| Original language | English |
|---|---|
| Journal | Neurology |
| Volume | 67 |
| Issue number | 5 |
| Pages (from-to) | 905-907 |
| Number of pages | 3 |
| ISSN | 0028-3878 |
| DOIs | |
| Publication status | Published - 01.01.2006 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being -
SDG 10 Reduced Inequalities
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
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