Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine

A. Sprenger; H. Rambold; T. Sander; S. Marti; K. Weber; D. Straumann; C. Helmchen

doi:10.1212/01.wnl.0000233829.76150.6b

Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine

A. Sprenger, H. Rambold, T. Sander, S. Marti, K. Weber, D. Straumann, C. Helmchen^*

^*Corresponding author for this work

Clinic of Neurology

21 Citations (Scopus)

Abstract

The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.

Original language	English
Journal	Neurology
Volume	67
Issue number	5
Pages (from-to)	905-907
Number of pages	3
ISSN	0028-3878
DOIs	https://doi.org/10.1212/01.wnl.0000233829.76150.6b
Publication status	Published - 01.01.2006

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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10.1212/01.wnl.0000233829.76150.6b

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abstract = "The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.",

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AU - Sprenger, A.

AU - Rambold, H.

AU - Sander, T.

AU - Marti, S.

AU - Weber, K.

AU - Straumann, D.

AU - Helmchen, C.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.

AB - The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.

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Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine

Abstract

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