Treatment of the gravity dependence of downbeat nystagmus with 3,4-diaminopyridine

A. Sprenger, H. Rambold, T. Sander, S. Marti, K. Weber, D. Straumann, C. Helmchen*

*Corresponding author for this work
21 Citations (Scopus)


The authors examined the effect of 3,4-diaminopyridine (DAP) on the gravity-dependent (GD) vertical ocular drift component of downbeat nystagmus in 11 patients with idiopathic cerebellar ataxia. With the head tilted downward (45°), DAP reduced slow phase velocity (SPV) in 7 of 11 patients by 36%. Its efficacy correlated with the GD modulation. DAP minimizes the gravity-independent velocity bias and may improve deficient inhibitory cerebellar control on overacting otolith-ocular reflexes.

Original languageEnglish
Issue number5
Pages (from-to)905-907
Number of pages3
Publication statusPublished - 01.01.2006

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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