Abstract
Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.
| Original language | English |
|---|---|
| Journal | Parkinsonism and Related Disorders |
| Volume | 79 |
| Pages (from-to) | 88-90 |
| Number of pages | 3 |
| ISSN | 1353-8020 |
| DOIs | |
| Publication status | Published - 01.10.2020 |
Funding
Ana Westenberger is funded by the Deutsche Forschungsgemeinschaft (FOR2488) and serves as a consultant for medical writing at Centogene AG. Christine Klein is an associate editor of Annals of Neurology. She serves as a medical advisor to Centogene AG for medical advice on genetic testing reports in the fields of movement disorders and dementia, excluding Parkinson's disease. She is funded by the Deutsche Forschungsgemeinschaft ( FOR 2488 ), the European Union , and received institutional support from the University of Lübeck for genetics research.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
