TY - JOUR
T1 - Transgenerational transduction of MPTP-induced alterations in a Parkinson's disease mouse model
AU - Alvarez-Fischer, D.
AU - Vernik, T.
AU - Vulinovic, F.
AU - Herrmann, A.
AU - Westenberger, A.
AU - Klein, C.
N1 - Publisher Copyright:
© 2020 Elsevier Ltd
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.
AB - Susceptibility to Parkinson's disease (PD) increases more than threefold in first-degree relatives of PD patients. Using a mouse model, we investigated in a proof-of-principle approach whether toxin exposure of F0 affects the F1 generation. We provide first evidence that disturbance of the nigrostriatal pathway can be transferred to the next generation.
UR - http://www.scopus.com/inward/record.url?scp=85090199481&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/6fef7405-e91b-3783-a3f2-be58bdac465a/
U2 - 10.1016/j.parkreldis.2020.08.017
DO - 10.1016/j.parkreldis.2020.08.017
M3 - Letters
C2 - 32906083
AN - SCOPUS:85090199481
SN - 1353-8020
VL - 79
SP - 88
EP - 90
JO - Parkinsonism and Related Disorders
JF - Parkinsonism and Related Disorders
ER -
