Transcranial sonography as early indicator for genetic Parkinson's disease

Christian Kier; Günter Seidel; Norbert Brüggemann; Johann Hagenah; Christine Klein; Til Aach; Alfred Mertins

doi:10.1007/978-3-540-89208-3_108

Transcranial sonography as early indicator for genetic Parkinson's disease

Christian Kier, Günter Seidel, Norbert Brüggemann, Johann Hagenah, Christine Klein, Til Aach, Alfred Mertins

Abstract

Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.

Original language	English
Title of host publication	4th European Conference of the International Federation for Medical and Biological Engineering
Editors	Jos Vander Sloten, Pascal Verdonck, Marc Nyssen, Jens Haueisen
Number of pages	4
Volume	22
Place of Publication	Berlin, Heidelberg
Publisher	Springer Berlin Heidelberg
Publication date	01.11.2009
Pages	456-459
ISBN (Print)	978-3-540-89207-6
ISBN (Electronic)	978-3-540-89208-3
DOIs	https://doi.org/10.1007/978-3-540-89208-3_108
Publication status	Published - 01.11.2009
Event	4th European Conference of the International Federation for Medical and Biological Engineering - Antwerp, Belgium Duration: 23.11.2008 → 27.11.2008 Conference number: 81647

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Kier, C., Seidel, G., Brüggemann, N., Hagenah, J., Klein, C., Aach, T., & Mertins, A. (2009). Transcranial sonography as early indicator for genetic Parkinson's disease. In J. Vander Sloten, P. Verdonck, M. Nyssen, & J. Haueisen (Eds.), 4th European Conference of the International Federation for Medical and Biological Engineering (Vol. 22, pp. 456-459). ( IFMBE Proceedings; Vol. 22). Springer Berlin Heidelberg. https://doi.org/10.1007/978-3-540-89208-3_108

Kier, Christian ; Seidel, Günter ; Brüggemann, Norbert et al. / Transcranial sonography as early indicator for genetic Parkinson's disease. 4th European Conference of the International Federation for Medical and Biological Engineering. editor / Jos Vander Sloten ; Pascal Verdonck ; Marc Nyssen ; Jens Haueisen. Vol. 22 Berlin, Heidelberg : Springer Berlin Heidelberg, 2009. pp. 456-459 ( IFMBE Proceedings).

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title = "Transcranial sonography as early indicator for genetic Parkinson's disease",

abstract = "Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.",

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Kier, C, Seidel, G, Brüggemann, N, Hagenah, J, Klein, C, Aach, T & Mertins, A 2009, Transcranial sonography as early indicator for genetic Parkinson's disease. in J Vander Sloten, P Verdonck, M Nyssen & J Haueisen (eds), 4th European Conference of the International Federation for Medical and Biological Engineering. vol. 22, IFMBE Proceedings, vol. 22, Springer Berlin Heidelberg, Berlin, Heidelberg, pp. 456-459, 4th European Conference of the International Federation for Medical and Biological Engineering, Antwerp, Belgium, 23.11.08. https://doi.org/10.1007/978-3-540-89208-3_108

Transcranial sonography as early indicator for genetic Parkinson's disease. / Kier, Christian; Seidel, Günter; Brüggemann, Norbert et al.
4th European Conference of the International Federation for Medical and Biological Engineering. ed. / Jos Vander Sloten; Pascal Verdonck; Marc Nyssen; Jens Haueisen. Vol. 22 Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. p. 456-459 ( IFMBE Proceedings; Vol. 22).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

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AU - Hagenah, Johann

AU - Klein, Christine

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AU - Mertins, Alfred

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N2 - Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.

AB - Early diagnosis of Parkinson's disease (PD) is of immense importance, since clinical symptoms do not occur until substantial parts of the brain stem have been irreparably damaged. Recent work suggests that by means of transcranial sonography (TCS) it is possible to determine the formation of monogenic forms of parkinsonism at a very early state. In TCS images, the mesencephalon shows a distinct hyperechogenic pattern in about 90% of patients with PD, despite its normal appearance on CT and MRI scans. At present, this pattern is manually segmented and the region size is used as an early PD indicator. In order to remove investigator dependence inherent to manual segmentation, we develop and validate semi-automatic features to serve as risk factors for PD manifestation. We show in a clinical study that some of the features correlate significantly with the presence of specific genetic mutations causing PD.

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ER -

Kier C, Seidel G, Brüggemann N, Hagenah J, Klein C, Aach T et al. Transcranial sonography as early indicator for genetic Parkinson's disease. In Vander Sloten J, Verdonck P, Nyssen M, Haueisen J, editors, 4th European Conference of the International Federation for Medical and Biological Engineering. Vol. 22. Berlin, Heidelberg: Springer Berlin Heidelberg. 2009. p. 456-459. ( IFMBE Proceedings). doi: 10.1007/978-3-540-89208-3_108

Transcranial sonography as early indicator for genetic Parkinson's disease

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