Transcranial oscillatory direct current stimulation during sleep improves declarative memory consolidation in children with attention-deficit/hyperactivity disorder to a level comparable to healthy controls

Alexander Prehn-Kristensen; Manuel Munz; Robert Göder; Ines Wilhelm; Katharina Korr; Wiebke Vahl; Christian D. Wiesner; Lioba Baving

doi:10.1016/j.brs.2014.07.036

Transcranial oscillatory direct current stimulation during sleep improves declarative memory consolidation in children with attention-deficit/hyperactivity disorder to a level comparable to healthy controls

Alexander Prehn-Kristensen^*, Manuel Munz, Robert Göder, Ines Wilhelm, Katharina Korr, Wiebke Vahl, Christian D. Wiesner, Lioba Baving

^*Corresponding author for this work

Clinic of Psychiatry and Psychotherapy

University of Kiel

85 Citations (Scopus)

Abstract

Background Slow oscillations (<1 Hz) during slow wave sleep (SWS) promote the consolidation of declarative memory. Children with attention-deficit/hyperactivity disorder (ADHD) have been shown to display deficits in sleep-dependent consolidation of declarative memory supposedly due to dysfunctional slow brain rhythms during SWS.

Objective Using transcranial oscillating direct current stimulation (toDCS) at 0.75 Hz, we investigated whether an externally triggered increase in slow oscillations during early SWS elevates memory performance in children with ADHD.

Methods: 12 children with ADHD underwent a toDCS and a sham condition in a double-blind crossover study design conducted in a sleep laboratory. Memory was tested using a 2D object-location task. In addition, 12 healthy children performed the same memory task in their home environment.

Results Stimulation enhanced slow oscillation power in children with ADHD and boosted memory performance to the same level as in healthy children.

Conclusions These data indicate that increasing slow oscillation power during sleep by toDCS can alleviate declarative memory deficits in children with ADHD.

Original language	English
Journal	Brain Stimulation
Volume	7
Issue number	6
Pages (from-to)	793-799
Number of pages	7
ISSN	1935-861X
DOIs	https://doi.org/10.1016/j.brs.2014.07.036
Publication status	Published - 01.11.2014

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Prehn-Kristensen, A., Munz, M., Göder, R., Wilhelm, I., Korr, K., Vahl, W., Wiesner, C. D., & Baving, L. (2014). Transcranial oscillatory direct current stimulation during sleep improves declarative memory consolidation in children with attention-deficit/hyperactivity disorder to a level comparable to healthy controls. Brain Stimulation, 7(6), 793-799. https://doi.org/10.1016/j.brs.2014.07.036

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title = "Transcranial oscillatory direct current stimulation during sleep improves declarative memory consolidation in children with attention-deficit/hyperactivity disorder to a level comparable to healthy controls",

abstract = "Background Slow oscillations (<1 Hz) during slow wave sleep (SWS) promote the consolidation of declarative memory. Children with attention-deficit/hyperactivity disorder (ADHD) have been shown to display deficits in sleep-dependent consolidation of declarative memory supposedly due to dysfunctional slow brain rhythms during SWS.Objective Using transcranial oscillating direct current stimulation (toDCS) at 0.75 Hz, we investigated whether an externally triggered increase in slow oscillations during early SWS elevates memory performance in children with ADHD.Methods: 12 children with ADHD underwent a toDCS and a sham condition in a double-blind crossover study design conducted in a sleep laboratory. Memory was tested using a 2D object-location task. In addition, 12 healthy children performed the same memory task in their home environment.Results Stimulation enhanced slow oscillation power in children with ADHD and boosted memory performance to the same level as in healthy children.Conclusions These data indicate that increasing slow oscillation power during sleep by toDCS can alleviate declarative memory deficits in children with ADHD.",

author = "Alexander Prehn-Kristensen and Manuel Munz and Robert G{\"o}der and Ines Wilhelm and Katharina Korr and Wiebke Vahl and Wiesner, {Christian D.} and Lioba Baving",

note = "Funding Information: This work was supported by a grant of the German Research Funding ( SFB 654 , “Plasticity and Sleep”). Publisher Copyright: {\textcopyright} 2014 The Authors. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

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Prehn-Kristensen, A, Munz, M, Göder, R, Wilhelm, I, Korr, K, Vahl, W, Wiesner, CD & Baving, L 2014, 'Transcranial oscillatory direct current stimulation during sleep improves declarative memory consolidation in children with attention-deficit/hyperactivity disorder to a level comparable to healthy controls', Brain Stimulation, vol. 7, no. 6, pp. 793-799. https://doi.org/10.1016/j.brs.2014.07.036

Transcranial oscillatory direct current stimulation during sleep improves declarative memory consolidation in children with attention-deficit/hyperactivity disorder to a level comparable to healthy controls. / Prehn-Kristensen, Alexander; Munz, Manuel; Göder, Robert et al.
In: Brain Stimulation, Vol. 7, No. 6, 01.11.2014, p. 793-799.

Research output: Journal Articles › Journal articles › Research › peer-review

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T1 - Transcranial oscillatory direct current stimulation during sleep improves declarative memory consolidation in children with attention-deficit/hyperactivity disorder to a level comparable to healthy controls

AU - Prehn-Kristensen, Alexander

AU - Munz, Manuel

AU - Göder, Robert

AU - Wilhelm, Ines

AU - Korr, Katharina

AU - Vahl, Wiebke

AU - Wiesner, Christian D.

AU - Baving, Lioba

N1 - Funding Information: This work was supported by a grant of the German Research Funding ( SFB 654 , “Plasticity and Sleep”). Publisher Copyright: © 2014 The Authors. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - Background Slow oscillations (<1 Hz) during slow wave sleep (SWS) promote the consolidation of declarative memory. Children with attention-deficit/hyperactivity disorder (ADHD) have been shown to display deficits in sleep-dependent consolidation of declarative memory supposedly due to dysfunctional slow brain rhythms during SWS.Objective Using transcranial oscillating direct current stimulation (toDCS) at 0.75 Hz, we investigated whether an externally triggered increase in slow oscillations during early SWS elevates memory performance in children with ADHD.Methods: 12 children with ADHD underwent a toDCS and a sham condition in a double-blind crossover study design conducted in a sleep laboratory. Memory was tested using a 2D object-location task. In addition, 12 healthy children performed the same memory task in their home environment.Results Stimulation enhanced slow oscillation power in children with ADHD and boosted memory performance to the same level as in healthy children.Conclusions These data indicate that increasing slow oscillation power during sleep by toDCS can alleviate declarative memory deficits in children with ADHD.

AB - Background Slow oscillations (<1 Hz) during slow wave sleep (SWS) promote the consolidation of declarative memory. Children with attention-deficit/hyperactivity disorder (ADHD) have been shown to display deficits in sleep-dependent consolidation of declarative memory supposedly due to dysfunctional slow brain rhythms during SWS.Objective Using transcranial oscillating direct current stimulation (toDCS) at 0.75 Hz, we investigated whether an externally triggered increase in slow oscillations during early SWS elevates memory performance in children with ADHD.Methods: 12 children with ADHD underwent a toDCS and a sham condition in a double-blind crossover study design conducted in a sleep laboratory. Memory was tested using a 2D object-location task. In addition, 12 healthy children performed the same memory task in their home environment.Results Stimulation enhanced slow oscillation power in children with ADHD and boosted memory performance to the same level as in healthy children.Conclusions These data indicate that increasing slow oscillation power during sleep by toDCS can alleviate declarative memory deficits in children with ADHD.

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Transcranial oscillatory direct current stimulation during sleep improves declarative memory consolidation in children with attention-deficit/hyperactivity disorder to a level comparable to healthy controls

Abstract

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