Towards an Optical Biopsy during Visceral Surgical Interventions

1 Citation (Scopus)

Abstract

Background: Cancer will replace cardiovascular diseases as the most frequent cause of death. Therefore, the goals of cancer treatment are prevention strategies and early detection by cancer screening and ideal stage therapy. From an oncological point of view, complete tumor resection is a significant prognostic factor. Optical coherence tomography (OCT) and confocal laser microscopy (CLM) are two techniques that have the potential to complement intraoperative frozen section analysis as in vivo and real-time optical biopsies. Summary: In this review we present both procedures and review the progress of evaluation for intraoperative application in visceral surgery. For visceral surgery, there are promising studies evaluating OCT and CLM; however, application during routine visceral surgical interventions is still lacking. Key Message: OCT and CLM are not competing but complementary approaches of tissue analysis to intraoperative frozen section analysis. Although intraoperative application of OCT and CLM is at an early stage, they are two promising techniques of intraoperative in vivo and real-time tissue examination. Additionally, deep learning strategies provide a significant supplement for automated tissue detection.

Original languageEnglish
JournalVisceral Medicine
Volume36
Issue number2
Pages (from-to)70-79
Number of pages10
ISSN2297-4725
DOIs
Publication statusPublished - 01.04.2020

Research Areas and Centers

  • Research Area: Luebeck Integrated Oncology Network (LION)

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