TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort

F. Demichelis; K. Fall; S. Perner; O. Andrén; F. Schmidt; S. R. Setlur; Y. Hoshida; J. M. Mosquera; Y. Pawitan; C. Lee; H. O. Adami; L. A. Mucci; P. W. Kantoff; S. O. Andersson; A. M. Chinnaiyan; J. E. Johansson; M. A. Rubin

doi:10.1038/sj.onc.1210237

TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort

F. Demichelis
, K. Fall
, S. Perner
, O. Andrén
, F. Schmidt
, S. R. Setlur
, Y. Hoshida
, J. M. Mosquera
, Y. Pawitan
, C. Lee
, H. O. Adami
, L. A. Mucci
, P. W. Kantoff
, S. O. Andersson
, A. M. Chinnaiyan
, J. E. Johansson
, M. A. Rubin^*

^*Corresponding author for this work

Institute of Pathology

Brigham and Women's Hospital
Karolinska Institutet
Örebro University Hospital
Harvard University
Broad Institute
University of Michigan
Dana-Farber Cancer Institute

572 Citations (Scopus)

Abstract

The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, P<0.01, 95% confidence interval=1.3-5.8). Quantitative reverse-transcription-polymerase chain reaction demonstrated high estrogen-regulated gene (ERG) expression to be associated with TMPRSS2:ERG fusion (P<0.005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.

Original language	English
Journal	Oncogene
Volume	26
Issue number	31
Pages (from-to)	4596-4599
Number of pages	4
ISSN	0950-9232
DOIs	https://doi.org/10.1038/sj.onc.1210237
Publication status	Published - 05.07.2007

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Demichelis, F., Fall, K., Perner, S., Andrén, O., Schmidt, F., Setlur, S. R., Hoshida, Y., Mosquera, J. M., Pawitan, Y., Lee, C., Adami, H. O., Mucci, L. A., Kantoff, P. W., Andersson, S. O., Chinnaiyan, A. M., Johansson, J. E., & Rubin, M. A. (2007). TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort. Oncogene, 26(31), 4596-4599. https://doi.org/10.1038/sj.onc.1210237

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title = "TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort",

abstract = "The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50\% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15\% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, P<0.01, 95\% confidence interval=1.3-5.8). Quantitative reverse-transcription-polymerase chain reaction demonstrated high estrogen-regulated gene (ERG) expression to be associated with TMPRSS2:ERG fusion (P<0.005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.",

author = "F. Demichelis and K. Fall and S. Perner and O. Andr{\'e}n and F. Schmidt and Setlur, \{S. R.\} and Y. Hoshida and Mosquera, \{J. M.\} and Y. Pawitan and C. Lee and Adami, \{H. O.\} and Mucci, \{L. A.\} and Kantoff, \{P. W.\} and Andersson, \{S. O.\} and Chinnaiyan, \{A. M.\} and Johansson, \{J. E.\} and Rubin, \{M. A.\}",

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doi = "10.1038/sj.onc.1210237",

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Demichelis, F, Fall, K, Perner, S, Andrén, O, Schmidt, F, Setlur, SR, Hoshida, Y, Mosquera, JM, Pawitan, Y, Lee, C, Adami, HO, Mucci, LA, Kantoff, PW, Andersson, SO, Chinnaiyan, AM, Johansson, JE & Rubin, MA 2007, 'TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort', Oncogene, vol. 26, no. 31, pp. 4596-4599. https://doi.org/10.1038/sj.onc.1210237

TY - JOUR

T1 - TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort

AU - Demichelis, F.

AU - Fall, K.

AU - Perner, S.

AU - Andrén, O.

AU - Schmidt, F.

AU - Setlur, S. R.

AU - Hoshida, Y.

AU - Mosquera, J. M.

AU - Pawitan, Y.

AU - Lee, C.

AU - Adami, H. O.

AU - Mucci, L. A.

AU - Kantoff, P. W.

AU - Andersson, S. O.

AU - Chinnaiyan, A. M.

AU - Johansson, J. E.

AU - Rubin, M. A.

PY - 2007/7/5

Y1 - 2007/7/5

N2 - The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, P<0.01, 95% confidence interval=1.3-5.8). Quantitative reverse-transcription-polymerase chain reaction demonstrated high estrogen-regulated gene (ERG) expression to be associated with TMPRSS2:ERG fusion (P<0.005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.

AB - The identification of the TMPRSS2:ERG fusion in prostate cancer suggests that distinct molecular subtypes may define risk for disease progression. In surgical series, TMPRSS2:ERG fusion was identified in 50% of the tumors. Here, we report on a population-based cohort of men with localized prostate cancers followed by expectant (watchful waiting) therapy with 15% (17/111) TMPRSS2:ERG fusion. We identified a statistically significant association between TMPRSS2:ERG fusion and prostate cancer specific death (cumulative incidence ratio=2.7, P<0.01, 95% confidence interval=1.3-5.8). Quantitative reverse-transcription-polymerase chain reaction demonstrated high estrogen-regulated gene (ERG) expression to be associated with TMPRSS2:ERG fusion (P<0.005). These data suggest that TMPRSS2:ERG fusion prostate cancers may have a more aggressive phenotype, possibly mediated through increased ERG expression.

UR - https://www.scopus.com/pages/publications/34248510706

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DO - 10.1038/sj.onc.1210237

M3 - Journal articles

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AN - SCOPUS:34248510706

SN - 0950-9232

VL - 26

SP - 4596

EP - 4599

JO - Oncogene

JF - Oncogene

IS - 31

ER -

TMPRSS2:ERG gene fusion associated with lethal prostate cancer in a watchful waiting cohort

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