Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material

Torsten Goldmann; Daniel Drömann; Marouane Marzouki; Udo Schimmel; Karsten Debel; Detlev Branscheid; Tobias Zeiser; Jan Rupp; Johannes Gerdes; Peter Zabel; Ekkehard Vollmer

doi:10.1016/j.prp.2005.07.006

Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material

Torsten Goldmann^*, Daniel Drömann, Marouane Marzouki, Udo Schimmel, Karsten Debel, Detlev Branscheid, Tobias Zeiser, Jan Rupp, Johannes Gerdes, Peter Zabel, Ekkehard Vollmer

^*Corresponding author for this work

20 Citations (Scopus)

Abstract

In this study, we describe a technique that allows for the production and the use of tissue microarrays (TMA) from HOPE-fixed, paraffin-embedded specimens. The combination of these two technologies unites the advantages of the high throughput aspects in TMA, with good preservation of nucleic acids, proteins, and morphology of HOPE-fixed tissues, thus substantially widening the capabilities presently available for molecular studies in paraffin-embedded tissues.

Original language	English
Journal	Pathology Research and Practice
Volume	201
Issue number	8-9
Pages (from-to)	599-602
Number of pages	4
ISSN	0344-0338
DOIs	https://doi.org/10.1016/j.prp.2005.07.006
Publication status	Published - 10.10.2005

Research Areas and Centers

Academic Focus: Center for Infection and Inflammation Research (ZIEL)

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.prp.2005.07.006

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Goldmann, T., Drömann, D., Marzouki, M., Schimmel, U., Debel, K., Branscheid, D., Zeiser, T., Rupp, J., Gerdes, J., Zabel, P., & Vollmer, E. (2005). Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material. Pathology Research and Practice, 201(8-9), 599-602. https://doi.org/10.1016/j.prp.2005.07.006

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abstract = "In this study, we describe a technique that allows for the production and the use of tissue microarrays (TMA) from HOPE-fixed, paraffin-embedded specimens. The combination of these two technologies unites the advantages of the high throughput aspects in TMA, with good preservation of nucleic acids, proteins, and morphology of HOPE-fixed tissues, thus substantially widening the capabilities presently available for molecular studies in paraffin-embedded tissues.",

author = "Torsten Goldmann and Daniel Dr{\"o}mann and Marouane Marzouki and Udo Schimmel and Karsten Debel and Detlev Branscheid and Tobias Zeiser and Jan Rupp and Johannes Gerdes and Peter Zabel and Ekkehard Vollmer",

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Goldmann, T, Drömann, D, Marzouki, M, Schimmel, U, Debel, K, Branscheid, D, Zeiser, T, Rupp, J, Gerdes, J, Zabel, P & Vollmer, E 2005, 'Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material', Pathology Research and Practice, vol. 201, no. 8-9, pp. 599-602. https://doi.org/10.1016/j.prp.2005.07.006

TY - JOUR

T1 - Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material

AU - Goldmann, Torsten

AU - Drömann, Daniel

AU - Marzouki, Marouane

AU - Schimmel, Udo

AU - Debel, Karsten

AU - Branscheid, Detlev

AU - Zeiser, Tobias

AU - Rupp, Jan

AU - Gerdes, Johannes

AU - Zabel, Peter

AU - Vollmer, Ekkehard

PY - 2005/10/10

Y1 - 2005/10/10

N2 - In this study, we describe a technique that allows for the production and the use of tissue microarrays (TMA) from HOPE-fixed, paraffin-embedded specimens. The combination of these two technologies unites the advantages of the high throughput aspects in TMA, with good preservation of nucleic acids, proteins, and morphology of HOPE-fixed tissues, thus substantially widening the capabilities presently available for molecular studies in paraffin-embedded tissues.

AB - In this study, we describe a technique that allows for the production and the use of tissue microarrays (TMA) from HOPE-fixed, paraffin-embedded specimens. The combination of these two technologies unites the advantages of the high throughput aspects in TMA, with good preservation of nucleic acids, proteins, and morphology of HOPE-fixed tissues, thus substantially widening the capabilities presently available for molecular studies in paraffin-embedded tissues.

UR - http://www.scopus.com/inward/record.url?scp=25444479391&partnerID=8YFLogxK

U2 - 10.1016/j.prp.2005.07.006

DO - 10.1016/j.prp.2005.07.006

M3 - Journal articles

C2 - 16259114

AN - SCOPUS:25444479391

SN - 0344-0338

VL - 201

SP - 599

EP - 602

JO - Pathology Research and Practice

JF - Pathology Research and Practice

IS - 8-9

ER -

Tissue microarrays from HOPE-fixed specimens allow for enhanced high throughput molecular analyses in paraffin-embedded material

Abstract

Research Areas and Centers

UN SDGs

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