Tippfehler im Genom: erbliche Ursachen von Herzerkrankungen

Ingrid Bræne; Benedikt Reiz; Jeanette Erdmann

doi:10.1007/s12268-013-0368-z

Tippfehler im Genom: erbliche Ursachen von Herzerkrankungen

Translated title of the contribution: Personalized medicine. Typos in the genome: Hereditary causes of heart diseases

Ingrid Bræne, Benedikt Reiz, Jeanette Erdmann^*

^*Corresponding author for this work

Institute of Cardiogenetics

Abstract

Coronary artery disease (CAD) and its clinical manifestation myocardial infarction (MI) is the leading cause of death in the western world. Besides environmental factors, genetic factors largely influence the risk of the disease. Recently, several CAD risk loci have been identified. Only one third of these loci influence traditional risk factors as lipid traits and blood pressure. However, two thirds are unforeseen risk loci that may give new insight to the pathomechanism of CAD. The goal of this research field is to reveal new therapeutic targets and enable a stratified treatment.

Translated title of the contribution	Personalized medicine. Typos in the genome: Hereditary causes of heart diseases
Original language	German
Journal	BioSpektrum
Volume	19
Issue number	6
Pages (from-to)	642-644
Number of pages	3
ISSN	0947-0867
DOIs	https://doi.org/10.1007/s12268-013-0368-z
Publication status	Published - 10.2013

Research Areas and Centers

Research Area: Medical Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12268-013-0368-z

Cite this

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abstract = "Coronary artery disease (CAD) and its clinical manifestation myocardial infarction (MI) is the leading cause of death in the western world. Besides environmental factors, genetic factors largely influence the risk of the disease. Recently, several CAD risk loci have been identified. Only one third of these loci influence traditional risk factors as lipid traits and blood pressure. However, two thirds are unforeseen risk loci that may give new insight to the pathomechanism of CAD. The goal of this research field is to reveal new therapeutic targets and enable a stratified treatment.",

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N2 - Coronary artery disease (CAD) and its clinical manifestation myocardial infarction (MI) is the leading cause of death in the western world. Besides environmental factors, genetic factors largely influence the risk of the disease. Recently, several CAD risk loci have been identified. Only one third of these loci influence traditional risk factors as lipid traits and blood pressure. However, two thirds are unforeseen risk loci that may give new insight to the pathomechanism of CAD. The goal of this research field is to reveal new therapeutic targets and enable a stratified treatment.

AB - Coronary artery disease (CAD) and its clinical manifestation myocardial infarction (MI) is the leading cause of death in the western world. Besides environmental factors, genetic factors largely influence the risk of the disease. Recently, several CAD risk loci have been identified. Only one third of these loci influence traditional risk factors as lipid traits and blood pressure. However, two thirds are unforeseen risk loci that may give new insight to the pathomechanism of CAD. The goal of this research field is to reveal new therapeutic targets and enable a stratified treatment.

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Tippfehler im Genom: erbliche Ursachen von Herzerkrankungen

Abstract

Research Areas and Centers

UN SDGs

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