Chronobiological factors may modulate the impact of sleep loss on glucose homeostasis. However, these interactions have not been systematically assessed in humans. Objective: To assess the effect of sleep loss during the late vs early night on glucose homeostasis. Design: Fifteen normal-weight men participated in three conditions of a randomized, balanced crossover study comprising two conditions with shortened sleep (i.e., 4 hours of sleep during the first or the second half of the night) and a control condition with 8 hours of sleep. Glucose, insulin, cortisol, and glucagon were measured. Insulin sensitivity and secretion were assessed with a Botnia clamp. Results: Compared with regular sleep duration, sleep loss reduced insulin sensitivity (M-value; P 5 0.031) irrespective of early- or late-night timing (P 5 0.691). The disposition index (i.e., the b-cell response adjusted for insulin sensitivity) also tended to be impaired by short sleep (P 5 0.056) but not by sleep timing (P 5 0.543). In contrast, sleep loss in the second half but not the first half of the night induced reductions in morning glucagon and cortisol levels (P,0.031) followed by a transient increase in cortisol (P , 0.044).

Original languageEnglish
Article numberjcem_201802636
JournalJournal of Clinical Endocrinology and Metabolism
Issue number7
Pages (from-to)2801-2808
Number of pages8
Publication statusPublished - 21.03.2019

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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