TY - JOUR
T1 - Time trends in incidence and mortality of cutaneous melanoma in Germany
AU - Garbe, C.
AU - Keim, U.
AU - Eigentler, T. K.
AU - Amaral, T.
AU - Katalinic, A.
AU - Holleczek, B.
AU - Martus, P.
AU - Leiter, U.
PY - 2019/7
Y1 - 2019/7
N2 - Objectives: To characterize incidence and mortality trends of cutaneous melanoma (CM) in Germany to extrapolate these data until 2030. Methods: We evaluated data from the Centre for Cancer Registry Data (1999–2012) and from the Saarland Cancer Registry (1970–2012). Age-standardized (according to the European Standard Population, WHO 1976) incidence and mortality rates [age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs)] and crude incidence and mortality rates [crude incidence rates (CIRs) and crude mortality rates (CMRs)] were analysed. Results: In entire Germany, ASIRs increased by 55% to 19.2 and CIRs by 77% to 26.0 new cases per 100 000 from 1999 to 2012. ASMRs remained stable, whereas CMR increased by 58% to 4.1 for males and by 30% to 3.0 for females per 100 000. In the Federal State of Saarland, ASIRs increased more than four-fold to 13.1, CIRs increased six–seven fold to 18.5/100 000 from 1970 to 2012. In the same period, ASMRs increased three-fold in males and two-fold in females to 2.5 and 1.6, whereas CMRs increased 5.5-fold in males and 3.5-fold in females to 3.9 and 3.2/100 000, mainly caused by steep increases of CIRs and CMRs in age groups ≥60 years. Projected CIRs will rise to 44–46 for males and 38–40 for females in 2030. Steepest increases were extrapolated for patients ≥60 years, especially for males, but are also expected for age groups of 40–59 years. In contrast, CIRs are anticipated to stabilize for subjects <40 years. Conclusions: There is a constant increase in incidence and mortality rates for CM in Germany. As the German population is ageing and the current population has already accumulated high levels of UV exposure, a further increase in melanoma incidence is projected for the future without signs of levelling-off.
AB - Objectives: To characterize incidence and mortality trends of cutaneous melanoma (CM) in Germany to extrapolate these data until 2030. Methods: We evaluated data from the Centre for Cancer Registry Data (1999–2012) and from the Saarland Cancer Registry (1970–2012). Age-standardized (according to the European Standard Population, WHO 1976) incidence and mortality rates [age-standardized incidence rates (ASIRs) and age-standardized mortality rates (ASMRs)] and crude incidence and mortality rates [crude incidence rates (CIRs) and crude mortality rates (CMRs)] were analysed. Results: In entire Germany, ASIRs increased by 55% to 19.2 and CIRs by 77% to 26.0 new cases per 100 000 from 1999 to 2012. ASMRs remained stable, whereas CMR increased by 58% to 4.1 for males and by 30% to 3.0 for females per 100 000. In the Federal State of Saarland, ASIRs increased more than four-fold to 13.1, CIRs increased six–seven fold to 18.5/100 000 from 1970 to 2012. In the same period, ASMRs increased three-fold in males and two-fold in females to 2.5 and 1.6, whereas CMRs increased 5.5-fold in males and 3.5-fold in females to 3.9 and 3.2/100 000, mainly caused by steep increases of CIRs and CMRs in age groups ≥60 years. Projected CIRs will rise to 44–46 for males and 38–40 for females in 2030. Steepest increases were extrapolated for patients ≥60 years, especially for males, but are also expected for age groups of 40–59 years. In contrast, CIRs are anticipated to stabilize for subjects <40 years. Conclusions: There is a constant increase in incidence and mortality rates for CM in Germany. As the German population is ageing and the current population has already accumulated high levels of UV exposure, a further increase in melanoma incidence is projected for the future without signs of levelling-off.
UR - http://www.scopus.com/inward/record.url?scp=85064567516&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/time-trends-incidence-mortality-cutaneous-melanoma-germany
U2 - 10.1111/jdv.15322
DO - 10.1111/jdv.15322
M3 - Journal articles
AN - SCOPUS:85064567516
SN - 0926-9959
VL - 33
SP - 1272
EP - 1280
JO - Journal of the European Academy of Dermatology and Venereology
JF - Journal of the European Academy of Dermatology and Venereology
IS - 7
ER -