Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers

Sebastian Karpf; Matthias Eibl; Wolfgang Wieser; Thomas Klein; Robert Huber

doi:10.1117/12.2183859

Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers

Sebastian Karpf, Matthias Eibl, Wolfgang Wieser, Thomas Klein, Robert Huber

Institute of Biomedical Optics

Abstract

We present a new concept for performing stimulated Raman spectroscopy and microscopy by employing rapidly wavelength swept Fourier Domain Mode locked (FDML) lasers [1]. FDML lasers are known for fastest imaging in swept-source optical coherence tomography [2, 3]. We employ this continuous and repetitive wavelength sweep to generate broadband, high resolution stimulated Raman spectra with a new, time-encoded (TICO) concept [4]. This allows for encoding and detecting the stimulated Raman gain on the FDML laser intensity directly in time. Therefore we use actively modulated pump lasers, which are electronically synchronized to the FDML laser, in combination with a fast analog-to-digital converter (ADC) at 1.8 GSamples/s. We present hyperspectral Raman images with color-coded, molecular contrast.

Original language	English
Title of host publication	Optical Coherence Imaging Techniques and Imaging in Scattering Media
Editors	Brett E. Bouma, Maciej Wojtkowski
Number of pages	6
Volume	95410F
Publisher	SPIE
Publication date	09.07.2015
Pages	95410F-95410F-6
ISBN (Print)	9781628417067
DOIs	https://doi.org/10.1117/12.2183859
Publication status	Published - 09.07.2015
Event	EUROPEAN CONFERENCES ON BIOMEDICAL OPTICS - München, Germany Duration: 21.06.2015 → 25.06.2015 Conference number: 131538 https://spie.org/conferences-and-exhibitions?webSyncID=8ea9e3e7-7b6b-4836-788d-177c8547e3b2&sessionGUID=7a4397d1-7ae8-5844-19e9-c62bcc516bb5&_ga=2.220047066.216408110.1526970521-1856364488.1526970521&SSO=1

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Karpf, S., Eibl, M., Wieser, W., Klein, T., & Huber, R. (2015). Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers. In B. E. Bouma, & M. Wojtkowski (Eds.), Optical Coherence Imaging Techniques and Imaging in Scattering Media (Vol. 95410F, pp. 95410F-95410F-6). (Proceedings of SPIE; Vol. 9541). SPIE. https://doi.org/10.1117/12.2183859

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title = "Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers",

abstract = "We present a new concept for performing stimulated Raman spectroscopy and microscopy by employing rapidly wavelength swept Fourier Domain Mode locked (FDML) lasers [1]. FDML lasers are known for fastest imaging in swept-source optical coherence tomography [2, 3]. We employ this continuous and repetitive wavelength sweep to generate broadband, high resolution stimulated Raman spectra with a new, time-encoded (TICO) concept [4]. This allows for encoding and detecting the stimulated Raman gain on the FDML laser intensity directly in time. Therefore we use actively modulated pump lasers, which are electronically synchronized to the FDML laser, in combination with a fast analog-to-digital converter (ADC) at 1.8 GSamples/s. We present hyperspectral Raman images with color-coded, molecular contrast.",

author = "Sebastian Karpf and Matthias Eibl and Wolfgang Wieser and Thomas Klein and Robert Huber",

year = "2015",

month = jul,

day = "9",

doi = "10.1117/12.2183859",

language = "English",

isbn = "9781628417067",

volume = "95410F",

series = "Proceedings of SPIE",

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editor = "Bouma, {Brett E. } and Wojtkowski, {Maciej }",

booktitle = "Optical Coherence Imaging Techniques and Imaging in Scattering Media",

note = "EUROPEAN CONFERENCES ON BIOMEDICAL OPTICS , ECBO 2015 ; Conference date: 21-06-2015 Through 25-06-2015",

url = "https://spie.org/conferences-and-exhibitions?webSyncID=8ea9e3e7-7b6b-4836-788d-177c8547e3b2&sessionGUID=7a4397d1-7ae8-5844-19e9-c62bcc516bb5&_ga=2.220047066.216408110.1526970521-1856364488.1526970521&SSO=1",

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Karpf, S, Eibl, M, Wieser, W, Klein, T & Huber, R 2015, Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers. in BE Bouma & M Wojtkowski (eds), Optical Coherence Imaging Techniques and Imaging in Scattering Media. vol. 95410F, Proceedings of SPIE, vol. 9541, SPIE, pp. 95410F-95410F-6, EUROPEAN CONFERENCES ON BIOMEDICAL OPTICS , München, Germany, 21.06.15. https://doi.org/10.1117/12.2183859

Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers. / Karpf, Sebastian; Eibl, Matthias; Wieser, Wolfgang et al.
Optical Coherence Imaging Techniques and Imaging in Scattering Media. ed. / Brett E. Bouma; Maciej Wojtkowski. Vol. 95410F SPIE, 2015. p. 95410F-95410F-6 (Proceedings of SPIE; Vol. 9541).

Research output: Chapters in Books/Reports/Conference Proceedings › Conference contribution › peer-review

TY - GEN

T1 - Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers

AU - Karpf, Sebastian

AU - Eibl, Matthias

AU - Wieser, Wolfgang

AU - Klein, Thomas

AU - Huber, Robert

N1 - Conference code: 131538

PY - 2015/7/9

Y1 - 2015/7/9

N2 - We present a new concept for performing stimulated Raman spectroscopy and microscopy by employing rapidly wavelength swept Fourier Domain Mode locked (FDML) lasers [1]. FDML lasers are known for fastest imaging in swept-source optical coherence tomography [2, 3]. We employ this continuous and repetitive wavelength sweep to generate broadband, high resolution stimulated Raman spectra with a new, time-encoded (TICO) concept [4]. This allows for encoding and detecting the stimulated Raman gain on the FDML laser intensity directly in time. Therefore we use actively modulated pump lasers, which are electronically synchronized to the FDML laser, in combination with a fast analog-to-digital converter (ADC) at 1.8 GSamples/s. We present hyperspectral Raman images with color-coded, molecular contrast.

AB - We present a new concept for performing stimulated Raman spectroscopy and microscopy by employing rapidly wavelength swept Fourier Domain Mode locked (FDML) lasers [1]. FDML lasers are known for fastest imaging in swept-source optical coherence tomography [2, 3]. We employ this continuous and repetitive wavelength sweep to generate broadband, high resolution stimulated Raman spectra with a new, time-encoded (TICO) concept [4]. This allows for encoding and detecting the stimulated Raman gain on the FDML laser intensity directly in time. Therefore we use actively modulated pump lasers, which are electronically synchronized to the FDML laser, in combination with a fast analog-to-digital converter (ADC) at 1.8 GSamples/s. We present hyperspectral Raman images with color-coded, molecular contrast.

U2 - 10.1117/12.2183859

DO - 10.1117/12.2183859

M3 - Conference contribution

SN - 9781628417067

VL - 95410F

T3 - Proceedings of SPIE

SP - 95410F-95410F-6

BT - Optical Coherence Imaging Techniques and Imaging in Scattering Media

A2 - Bouma, Brett E.

A2 - Wojtkowski, Maciej

PB - SPIE

T2 - EUROPEAN CONFERENCES ON BIOMEDICAL OPTICS

Y2 - 21 June 2015 through 25 June 2015

ER -

Time-encoded Raman scattering (TICO-Raman) with Fourier domain mode locked (FDML) lasers

Abstract

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