TY - JOUR
T1 - Time course of neopterin and cytokines after an extreme bicycle race at moderate altitude
AU - Deetjen, Christian
AU - Mair, Johannes
AU - Herold, Manfred
AU - Wiedermann, Franz
AU - Hobisch-Hagen, Petra
AU - Jelkmann, Wolfgang
AU - Hoffmann, Georg
AU - Schobersberger, Wolfgang
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 1997/9
Y1 - 1997/9
N2 - Endurance exercise induces several alterations in the immune and hematological system. At present it is unknown whether exercise under hypoxic conditions can modulate these changes. We investigated the effects of a prolonged endurance bicycle exercise in 8 healthy athletes (Oetztal Bicycle Marathon, OEBM; distance 230 km; vertical displacement 5000 m) on serum concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-α), neopterin as well as erythropoietin (EPO). Blood was collected before (A), immediately after the race (B), one (C), two (D), three (E) as well as five (F) days after the OEBM. We could demonstrate that IL-6 was increased significantly after exercise termination, whereas IL-1β and TNF-α were unchanged. Neopterin was significantly elevated from B to D, indicating an activation of the cellular immune system. Serum EPO was significantly increased from day 1 to day 5 after exercise which might reflect the combination of hypoxia and postexercise hemodilution.
AB - Endurance exercise induces several alterations in the immune and hematological system. At present it is unknown whether exercise under hypoxic conditions can modulate these changes. We investigated the effects of a prolonged endurance bicycle exercise in 8 healthy athletes (Oetztal Bicycle Marathon, OEBM; distance 230 km; vertical displacement 5000 m) on serum concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-a (TNF-α), neopterin as well as erythropoietin (EPO). Blood was collected before (A), immediately after the race (B), one (C), two (D), three (E) as well as five (F) days after the OEBM. We could demonstrate that IL-6 was increased significantly after exercise termination, whereas IL-1β and TNF-α were unchanged. Neopterin was significantly elevated from B to D, indicating an activation of the cellular immune system. Serum EPO was significantly increased from day 1 to day 5 after exercise which might reflect the combination of hypoxia and postexercise hemodilution.
UR - http://www.scopus.com/inward/record.url?scp=0030666059&partnerID=8YFLogxK
U2 - 10.1515/pteridines.1997.8.3.195
DO - 10.1515/pteridines.1997.8.3.195
M3 - Journal articles
AN - SCOPUS:0030666059
SN - 0933-4807
VL - 8
SP - 195
EP - 200
JO - Pteridines
JF - Pteridines
IS - 3
ER -