Projects per year
Abstract
In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH ‘central’ metabolic action, which was recently discovered in rodent models and challenged the previous ‘peripheral’ paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.
| Original language | English |
|---|---|
| Journal | Trends in Endocrinology and Metabolism |
| Volume | 32 |
| Issue number | 9 |
| Pages (from-to) | 659-671 |
| Number of pages | 13 |
| ISSN | 1043-2760 |
| DOIs | |
| Publication status | Published - 09.2021 |
Funding
The research leading to these results has received funding from the Xunta de Galicia (M.L.: 2016-PG068 ), Ministerio de Economía y Competitividad (MINECO) co-funded by the FEDER Program of the EU (C.D.: BFU2017-87721-P ; M.L.: RTI2018-101840-B-I00 ); the Atresmedia Corporación (M.L.); ‘la Caixa’ Foundation (ID 100010434 ) under the agreement LCF/PR/HR19/52160022 (M.L.); and the German Research Council (DFG) in the framework of the CRC/TR-296 ‘Local Control of Thyroid Hormone Action’ (J.M.). CiMUS is supported by the Xunta de Galicia ( 2016-2019 , ED431G/05 ). CIBER de Fisiopatología de la Obesidad y Nutrición is an initiative of ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The research leading to these results has received funding from the Xunta de Galicia (M.L.: 2016-PG068), Ministerio de Econom?a y Competitividad (MINECO) co-funded by the FEDER Program of the EU (C.D.: BFU2017-87721-P; M.L.: RTI2018-101840-B-I00); the Atresmedia Corporaci?n (M.L.); ?la Caixa? Foundation (ID 100010434) under the agreement LCF/PR/HR19/52160022 (M.L.); and the German Research Council (DFG) in the framework of the CRC/TR-296 ?Local Control of Thyroid Hormone Action? (J.M.). CiMUS is supported by the Xunta de Galicia (2016-2019, ED431G/05). CIBER de Fisiopatolog?a de la Obesidad y Nutrici?n is an initiative of ISCIII. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No interests are declared.
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
DFG Research Classification Scheme
- 2.22-17 Endocrinology, Diabetology, Metabolism
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CRC/TRR 296 LocoTact: Local control of TH action
Führer-Sakel, D. (Speaker, Coordinator), Mittag, J. (Co-Speaker), Kühnen, P. (Co-Speaker), Heuer, H. (Principal Investigator (PI)), Schwaninger, M. (Principal Investigator (PI)), Müller-Fielitz, H. (Principal Investigator (PI)), Bechmann, I. (Principal Investigator (PI)), Biebermann, H. (Principal Investigator (PI)), Müller, T. (Principal Investigator (PI)), Pfluger, P. (Principal Investigator (PI)), Krude, H. (Principal Investigator (PI)), Schülke-Gerstenfeld, M. (Principal Investigator (PI)), Cirkel, A. (Principal Investigator (PI)), Münte, T. (Principal Investigator (PI)), Kleinschnitz, C. (Principal Investigator (PI)), Langhauser, F. (Principal Investigator (PI)), Engel, D. R. (Principal Investigator (PI)), Möller, L. (Principal Investigator (PI)), Kaiser, F. (Principal Investigator (PI)), Oster, H. (Principal Investigator (PI)), Kirchner, H. (Principal Investigator (PI)), Spranger, J. (Principal Investigator (PI)), Tacke, F. (Principal Investigator (PI)), Wirth, E. K. (Principal Investigator (PI)), Köhrle, J. (Principal Investigator (PI)), Schomburg, L. (Principal Investigator (PI)), Lange, C. M. (Principal Investigator (PI)), Zwanziger, D. (Principal Investigator (PI)), Mayerl, S. (Principal Investigator (PI)), Stachelscheid, H. (Principal Investigator (PI)), Opitz, R. (Principal Investigator (PI)), Prasuhn, J. (Principal Investigator (PI)), Lorenz, K. (Principal Investigator (PI)), Köster, J. (Principal Investigator (PI)), Mai, K. (Principal Investigator (PI)), Püngel, T. (Principal Investigator (PI)), Obermayer, B. (Principal Investigator (PI)) & Rehwald, S. (Principal Investigator (PI))
01.01.20 → 31.12.25
Project: DFG Joint Research › DFG Collaborative Research Centers (CRC)