Thyroid wars: the rise of central actions

Valentina Capelli; Carlos Diéguez; Jens Mittag; Miguel López

doi:10.1016/j.tem.2021.05.006

Thyroid wars: the rise of central actions

Valentina Capelli, Carlos Diéguez, Jens Mittag^*, Miguel López

^*Corresponding author for this work

Institute of Endocrinology and Diabetes

13 Citations (Scopus)

Abstract

In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH ‘central’ metabolic action, which was recently discovered in rodent models and challenged the previous ‘peripheral’ paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.

Original language	English
Journal	Trends in Endocrinology and Metabolism
Volume	32
Issue number	9
Pages (from-to)	659-671
Number of pages	13
ISSN	1043-2760
DOIs	https://doi.org/10.1016/j.tem.2021.05.006
Publication status	Published - 09.2021

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

2.22-17 Endocrinology, Diabetology, Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.tem.2021.05.006

Cite this

@article{578ce5598b07478e80fe40fb85699851,

title = "Thyroid wars: the rise of central actions",

abstract = "In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH {\textquoteleft}central{\textquoteright} metabolic action, which was recently discovered in rodent models and challenged the previous {\textquoteleft}peripheral{\textquoteright} paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.",

author = "Valentina Capelli and Carlos Di{\'e}guez and Jens Mittag and Miguel L{\'o}pez",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Ltd",

year = "2021",

month = sep,

doi = "10.1016/j.tem.2021.05.006",

language = "English",

volume = "32",

pages = "659--671",

journal = "Trends in Endocrinology and Metabolism",

issn = "1043-2760",

number = "9",

}

TY - JOUR

T1 - Thyroid wars

T2 - the rise of central actions

AU - Capelli, Valentina

AU - Diéguez, Carlos

AU - Mittag, Jens

AU - López, Miguel

PY - 2021/9

Y1 - 2021/9

N2 - In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH ‘central’ metabolic action, which was recently discovered in rodent models and challenged the previous ‘peripheral’ paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.

AB - In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH ‘central’ metabolic action, which was recently discovered in rodent models and challenged the previous ‘peripheral’ paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.

UR - http://www.scopus.com/inward/record.url?scp=85110586535&partnerID=8YFLogxK

U2 - 10.1016/j.tem.2021.05.006

DO - 10.1016/j.tem.2021.05.006

M3 - Scientific review articles

C2 - 34294513

AN - SCOPUS:85110586535

SN - 1043-2760

VL - 32

SP - 659

EP - 671

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 9

ER -

Thyroid wars: the rise of central actions

Abstract

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

Other files and links

Fingerprint

CRC/Transregio TRR 296 LocoTact: Local control of TH action

Cite this

Thyroid wars: the rise of central actions

Abstract

Research Areas and Centers

DFG Research Classification Scheme

UN SDGs

Access to Document

Other files and links

Fingerprint

Projects

CRC/Transregio TRR 296 LocoTact: Local control of TH action

Cite this