Thyroid wars: the rise of central actions

Valentina Capelli, Carlos Diéguez, Jens Mittag*, Miguel López

*Corresponding author for this work
13 Citations (Scopus)


In the field of thyroid hormone (TH) action on energy balance, huge advances have been achieved in the past decade, from human, animal, and in vitro studies. A key achievement was the demonstration of the TH ‘central’ metabolic action, which was recently discovered in rodent models and challenged the previous ‘peripheral’ paradigm. In this opinion, we dissect and try to unify the two paradigms, from analyzing the respective bench models to extrapolating the possible translational bedside implications.

Original languageEnglish
JournalTrends in Endocrinology and Metabolism
Issue number9
Pages (from-to)659-671
Number of pages13
Publication statusPublished - 09.2021

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

DFG Research Classification Scheme

  • 205-17 Endocrinology, Diabetology, Metabolism

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