Abstract
The Belgrade laboratory (b/b) rat has a unique hereditary defect in iron metabolism, that induces profound anemia and hypoxia. Serum thyroid hormone levels in anemic b/b rats and non-anemic controls (+/+) were investigated using radio-immunoassay (RIA). Hematologic parameters and erythropoietin (Epo) concentrations were also determined in the anemic b/b and control rats. Our results confirmed the existence of severe anemia and extremely high Epo concentrations in the anemic b/b rats. The results for serum thyroid hormone concentrations imply the existence of thyroid gland hypofunction in the b/b rats. These preliminary results points to the b/b rat anemic syndrome as a unique model, which is not only interesting for the hematologist, but also for the endocrinologist.
| Original language | English |
|---|---|
| Journal | Acta Veterinaria |
| Volume | 47 |
| Issue number | 5-6 |
| Pages (from-to) | 277-282 |
| Number of pages | 6 |
| ISSN | 0567-8315 |
| Publication status | Published - 1997 |
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)
