Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia

Melchior Lauten; Girmay Asgedom; Karl Welte; Martin Schrappe; Martin Stanulla

Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia

Melchior Lauten^*, Girmay Asgedom, Karl Welte, Martin Schrappe, Martin Stanulla

^*Corresponding author for this work

Clinic of Pediatric and Adolescent Medicine

Hannover Medical School

43 Citations (Scopus)

Abstract

We investigated a tandem-repeat polymorphism within the promoter region of the thymidylate synthase gene in 40 matched pairs of relapsed and non-relapsed childhood B-cell precursor acute lymphoblastic leukemia patients. This polymorphism has previously been suggested to influence treatment outcome in childhood acute lymphoblastic leukemia. In our study, no association between thymidylate synthase genotype and risk of relapse was found.

Original language	English
Journal	Haematologica
Volume	88
Issue number	3
Pages (from-to)	353-354
Number of pages	2
ISSN	0390-6078
Publication status	Published - 01.03.2003

Research Areas and Centers

Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)

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abstract = "We investigated a tandem-repeat polymorphism within the promoter region of the thymidylate synthase gene in 40 matched pairs of relapsed and non-relapsed childhood B-cell precursor acute lymphoblastic leukemia patients. This polymorphism has previously been suggested to influence treatment outcome in childhood acute lymphoblastic leukemia. In our study, no association between thymidylate synthase genotype and risk of relapse was found.",

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T1 - Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia

AU - Lauten, Melchior

AU - Asgedom, Girmay

AU - Welte, Karl

AU - Schrappe, Martin

AU - Stanulla, Martin

PY - 2003/3/1

Y1 - 2003/3/1

N2 - We investigated a tandem-repeat polymorphism within the promoter region of the thymidylate synthase gene in 40 matched pairs of relapsed and non-relapsed childhood B-cell precursor acute lymphoblastic leukemia patients. This polymorphism has previously been suggested to influence treatment outcome in childhood acute lymphoblastic leukemia. In our study, no association between thymidylate synthase genotype and risk of relapse was found.

AB - We investigated a tandem-repeat polymorphism within the promoter region of the thymidylate synthase gene in 40 matched pairs of relapsed and non-relapsed childhood B-cell precursor acute lymphoblastic leukemia patients. This polymorphism has previously been suggested to influence treatment outcome in childhood acute lymphoblastic leukemia. In our study, no association between thymidylate synthase genotype and risk of relapse was found.

UR - http://www.scopus.com/inward/record.url?scp=0037346011&partnerID=8YFLogxK

M3 - Journal articles

C2 - 12651279

AN - SCOPUS:0037346011

SN - 0390-6078

VL - 88

SP - 353

EP - 354

JO - Haematologica

JF - Haematologica

IS - 3

ER -

Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia

Abstract

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