The glycoprotein thrombopoietin (TPO) is the major stimulator of megakaryopoiesis and platelet production. Hepatocytes express TPO mRNA at a constant rate. The plasma TPO level is inversely correlated to the mass of megakaryocytes and platelets, which degrade the hormone following its binding to specific membrane receptors.
|News in Physiological Sciences
|Number of pages
|Published - 02.2002
Research Areas and Centers
- Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)