Thrombopoietin: The novel hepatic hormone

Eva Maria Wolber*, Wolfgang Jelkmann

*Corresponding author for this work
66 Citations (Scopus)


The glycoprotein thrombopoietin (TPO) is the major stimulator of megakaryopoiesis and platelet production. Hepatocytes express TPO mRNA at a constant rate. The plasma TPO level is inversely correlated to the mass of megakaryocytes and platelets, which degrade the hormone following its binding to specific membrane receptors.

Original languageEnglish
JournalNews in Physiological Sciences
Issue number1
Pages (from-to)6-10
Number of pages5
Publication statusPublished - 02.2002

Research Areas and Centers

  • Academic Focus: Center for Brain, Behavior and Metabolism (CBBM)


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