Thrombophile Gerinnungsstörungen als Risikofaktoren für habituelle Aborte

Translated title of the contribution: Thrombophilic coagulation disorders as risk factors for recurrent spontaneous abortions

M. K. Bohlmann, D. W. Luedders, J. Weichert, K. Baumann, M. Thill, K. Diedrich, E. Schleussner, A. Hornemann

11 Citations (Scopus)


Recurrent spontaneous abortions - three or more consecutive miscarriages of the same couple - are traditionally associated with genetic, anatomic, immunologic, endocrine, and questionable infectious factors. However, there is growing evidence that changes in the haemostaseologic maternal pathway may play a role in the development of pregnancy complications. Maternal thrombophilic disorders, whether hereditary or acquired, can be associated with a significantly elevated risk for miscarriage. Besides hereditary changes of the coagulation system (e.g. factor V Leiden mutation, prothrombin mutation, protein S deficiency), it is the acquired thrombophilic disorder of the antiphospholipid syndrome that especially symbolizes a major risk factor for recurrent miscarriages; however, it can be treated adequately with combination anticoagulant therapy. This review summarizes the current knowledge concerning the diagnosis and therapeutic options in patients with recurrent abortions and maternal thrombophilic disorders.

Translated title of the contributionThrombophilic coagulation disorders as risk factors for recurrent spontaneous abortions
Original languageGerman
Issue number1
Pages (from-to)17-24
Number of pages8
Publication statusPublished - 01.2009


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