Three-center feasibility of lung clearance index in infants and preschool children with cystic fibrosis and other lung diseases

Mirjam Stahl*, Simon Y. Graeber, Cornelia Joachim, Sandra Barth, Isabell Ricklefs, Gesa Diekmann, Matthias V. Kopp, Lutz Naehrlich, Marcus A. Mall

*Corresponding author for this work
14 Citations (Scopus)

Abstract

Background: Lung clearance index (LCI) detects early ventilation inhomogeneity and has been suggested as sensitive endpoint in multicenter intervention trials in infants and preschoolers with cystic fibrosis (CF). However, the feasibility of multicenter LCI in this age group has not been determined. We, therefore, investigated the feasibility of LCI in infants and preschoolers with and without CF in a three-center setting. Methods: Following central training, standardized SF6-MBW measurements were performed in 73 sedated children (10 controls, 49 with CF and 14 with other lung diseases), mean age 2.3 ± 1.2 years across three centers, and data were analyzed centrally. Results: Overall success rate of LCI measurements was 91.8% ranging from 78.9% to 100% across study sites. LCI was increased in patients with CF (P < 0.05) and with other lung diseases (P < 0.05) compared to controls. Conclusion: Our results support feasibility of LCI as multicenter endpoint in clinical trials in infants and preschoolers with CF.

Original languageEnglish
JournalJournal of Cystic Fibrosis
Volume17
Issue number2
Pages (from-to)249-255
Number of pages7
ISSN1569-1993
DOIs
Publication statusPublished - 03.2018

Research Areas and Centers

  • Academic Focus: Center for Infection and Inflammation Research (ZIEL)

Fingerprint

Dive into the research topics of 'Three-center feasibility of lung clearance index in infants and preschool children with cystic fibrosis and other lung diseases'. Together they form a unique fingerprint.

Cite this