TY - JOUR
T1 - Thiazolidone derivatives as inhibitors of chikungunya virus
AU - Jadav, Surender Singh
AU - Sinha, Barij Nayan
AU - Hilgenfeld, Rolf
AU - Pastorino, Boris
AU - De Lamballerie, Xavier
AU - Jayaprakash, Venkatesan
PY - 2014/1/1
Y1 - 2014/1/1
N2 - A series of arylalkylidene derivatives of 1,3-thiazolidin-4-one (1-20) were synthesized and tested for their antiviral activity against chikungunya virus (LR2006-OPY1) in Vero cell culture by CPE reduction assay. Five compounds (7-9, 16 and 19) were identified to have anti-ChikV activity at lower micro molar concentration. The compounds 7, 8, 9, 16 and 19 inhibited the virus at 0.42, 4.2, 3.6, 40.1 and 6.8 μM concentrations respectively. Molecular docking simulation has been carried out using the available X-ray crystal structure of the ChikV nsp2 protease, in order to elucidate the possible mechanism of action. Interaction of ligands with ChikV nsp2 protease (PDB Code: 3TRK) suggested the possible mechanism of protease inhibition to act as potent anti-ChikV agents.
AB - A series of arylalkylidene derivatives of 1,3-thiazolidin-4-one (1-20) were synthesized and tested for their antiviral activity against chikungunya virus (LR2006-OPY1) in Vero cell culture by CPE reduction assay. Five compounds (7-9, 16 and 19) were identified to have anti-ChikV activity at lower micro molar concentration. The compounds 7, 8, 9, 16 and 19 inhibited the virus at 0.42, 4.2, 3.6, 40.1 and 6.8 μM concentrations respectively. Molecular docking simulation has been carried out using the available X-ray crystal structure of the ChikV nsp2 protease, in order to elucidate the possible mechanism of action. Interaction of ligands with ChikV nsp2 protease (PDB Code: 3TRK) suggested the possible mechanism of protease inhibition to act as potent anti-ChikV agents.
UR - http://www.scopus.com/inward/record.url?scp=84908447953&partnerID=8YFLogxK
U2 - 10.1016/j.ejmech.2014.10.042
DO - 10.1016/j.ejmech.2014.10.042
M3 - Journal articles
C2 - 25462237
AN - SCOPUS:84908447953
SN - 0223-5234
VL - 89
SP - 172
EP - 178
JO - European Journal of Medicinal Chemistry
JF - European Journal of Medicinal Chemistry
ER -