Therapy Failure and Resistance Mechanism in Eyelid and Ocular Surface Tumors

Xiaojun Ju; Piotr Gaca; Wanlin Fan; Alexander C. Rokohl; Yongwei Guo; Philomena A. Wawer Matos; Steffen Emmert; Vinodh Kakkassery; Ludwig M. Heindl

doi:10.33594/000000560

Therapy Failure and Resistance Mechanism in Eyelid and Ocular Surface Tumors

Xiaojun Ju, Piotr Gaca, Wanlin Fan, Alexander C. Rokohl, Yongwei Guo, Philomena A. Wawer Matos, Steffen Emmert, Vinodh Kakkassery, Ludwig M. Heindl

Clinic of Ophtalmology

5 Citations (Scopus)

Abstract

Malignant tumors of the eyelids and ocular surface are common ocular malignancies. At present, surgical treatment is mostly the first choice for these types of tumors. However, postoperative tumor recurrence and metastasis are still regarded as failures in the treatment of such malignancies. Based on this, malignant tumors of the eyelid and ocular surface are sometimes accompanied by local adjuvant chemotherapy and systemic chemotherapy to treat patients with relapse, invasion of adjacent tissues, and systemic metastases. Still, drug resistance greatly affects the treatment effect. This review lists several mechanisms of recurrence and metastasis of ocular surface and eyelid tumors after surgery, as well as mechanisms that may lead to non-surgical treatment or drug resistance.

Original language	English
Journal	Neuro-Signals
Volume	30
Issue number	S1
Pages (from-to)	21-38
Number of pages	18
ISSN	1424-862X
DOIs	https://doi.org/10.33594/000000560
Publication status	Published - 25.08.2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Research Areas and Centers

Research Area: Luebeck Integrated Oncology Network (LION)
Centers: University Cancer Center Schleswig-Holstein (UCCSH)

DFG Research Classification Scheme

2.23-11 Ophthalmology
2.22-14 Hematology, Oncology

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10.33594/000000560

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@article{e079170bb98342fe8cab449dfad9d31c,

title = "Therapy Failure and Resistance Mechanism in Eyelid and Ocular Surface Tumors",

abstract = "Malignant tumors of the eyelids and ocular surface are common ocular malignancies. At present, surgical treatment is mostly the first choice for these types of tumors. However, postoperative tumor recurrence and metastasis are still regarded as failures in the treatment of such malignancies. Based on this, malignant tumors of the eyelid and ocular surface are sometimes accompanied by local adjuvant chemotherapy and systemic chemotherapy to treat patients with relapse, invasion of adjacent tissues, and systemic metastases. Still, drug resistance greatly affects the treatment effect. This review lists several mechanisms of recurrence and metastasis of ocular surface and eyelid tumors after surgery, as well as mechanisms that may lead to non-surgical treatment or drug resistance.",

author = "Xiaojun Ju and Piotr Gaca and Wanlin Fan and Rokohl, \{Alexander C.\} and Yongwei Guo and \{Wawer Matos\}, \{Philomena A.\} and Steffen Emmert and Vinodh Kakkassery and Heindl, \{Ludwig M.\}",

note = "Publisher Copyright: {\textcopyright} Copyright by the Author(s). Published by Cell Physiol Biochem Press.",

year = "2022",

month = aug,

day = "25",

doi = "10.33594/000000560",

language = "English",

volume = "30",

pages = "21--38",

journal = "Neuro-Signals",

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TY - JOUR

T1 - Therapy Failure and Resistance Mechanism in Eyelid and Ocular Surface Tumors

AU - Ju, Xiaojun

AU - Gaca, Piotr

AU - Fan, Wanlin

AU - Rokohl, Alexander C.

AU - Guo, Yongwei

AU - Wawer Matos, Philomena A.

AU - Emmert, Steffen

AU - Kakkassery, Vinodh

AU - Heindl, Ludwig M.

PY - 2022/8/25

Y1 - 2022/8/25

N2 - Malignant tumors of the eyelids and ocular surface are common ocular malignancies. At present, surgical treatment is mostly the first choice for these types of tumors. However, postoperative tumor recurrence and metastasis are still regarded as failures in the treatment of such malignancies. Based on this, malignant tumors of the eyelid and ocular surface are sometimes accompanied by local adjuvant chemotherapy and systemic chemotherapy to treat patients with relapse, invasion of adjacent tissues, and systemic metastases. Still, drug resistance greatly affects the treatment effect. This review lists several mechanisms of recurrence and metastasis of ocular surface and eyelid tumors after surgery, as well as mechanisms that may lead to non-surgical treatment or drug resistance.

AB - Malignant tumors of the eyelids and ocular surface are common ocular malignancies. At present, surgical treatment is mostly the first choice for these types of tumors. However, postoperative tumor recurrence and metastasis are still regarded as failures in the treatment of such malignancies. Based on this, malignant tumors of the eyelid and ocular surface are sometimes accompanied by local adjuvant chemotherapy and systemic chemotherapy to treat patients with relapse, invasion of adjacent tissues, and systemic metastases. Still, drug resistance greatly affects the treatment effect. This review lists several mechanisms of recurrence and metastasis of ocular surface and eyelid tumors after surgery, as well as mechanisms that may lead to non-surgical treatment or drug resistance.

UR - https://www.scopus.com/pages/publications/85136538549

U2 - 10.33594/000000560

DO - 10.33594/000000560

M3 - Scientific review articles

C2 - 36005157

AN - SCOPUS:85136538549

SN - 1424-862X

VL - 30

SP - 21

EP - 38

JO - Neuro-Signals

JF - Neuro-Signals

IS - S1

ER -

Therapy Failure and Resistance Mechanism in Eyelid and Ocular Surface Tumors

Abstract

UN SDGs

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DFG Research Classification Scheme

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